3 citations
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February 1985 in “PubMed” This report describes a case in which the use of the beta-blocker nadolol was associated with infiltrative dermatitis and significant alopecia, which resolved and resulted in total hair regrowth after discontinuation of the drug.
This study found that finite element analysis-guided design improved bubble microneedles' controlled tip separation and insertion strength, supporting effective transdermal and sublingual drug delivery.
1 citations
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October 2022 in “Journal of Cosmetic Dermatology” In this study, combining 2% minoxidil with weekly microneedling significantly improved hair regrowth in women with female pattern hair loss compared to using minoxidil alone, with an 85% effective rate reported in the group receiving both treatments over a 24-week period.
June 2025 in “Archives of Dermatological Research” 8 citations
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March 2025 in “Journal of Drug Delivery Science and Technology” Dissolvable microneedles are a promising, painless method for effective skin treatments.
24 citations
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September 2014 in “Drug Delivery” This study found that pretreating mouse skin with microneedles significantly enhanced the hair growth inhibitory effect of eflornithine cream, likely by improving its skin permeation.
March 2023 in “The Journal of Urology” This study observed that despite the increase in nocturia cases from 2016 to 2021, the use of pharmacotherapy for the condition declined, suggesting potential undertreatment.
February 2024 in “Dermatology Reports” In this randomized controlled trial, combining 4-weekly microneedling with 5% minoxidil significantly increased hair density and diameter in men with androgenetic alopecia compared to minoxidil alone, while side effects were minor and tolerable.
May 2026 in “Reactions Weekly” September 2024 in “Actas Dermo-Sifiliográficas” This study discusses trichodynia, a painful scalp condition often linked to various forms of alopecia and psychiatric comorbidities, highlighting its clinical diagnosis, lack of specific treatments, and suggesting the need for more research to explore effective therapies.
27 citations
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December 2005 in “Journal of Cosmetic Dermatology” This study found that topical application of niacin derivatives significantly increased hair fullness in women with female pattern hair loss compared to a placebo after six months.
4 citations
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March 1999 in “International Journal of STD & AIDS” This report details a case of severe recurrent bacterial vaginosis in a woman with Netherton's syndrome.
August 2026 in “Anais Brasileiros de Dermatologia” In this case report, a 24-year-old woman with Down syndrome effectively managed coexisting alopecia areata and hidradenitis suppurativa using upadacitinib, following partial success with previous treatments.
January 2026 in “British Journal of Dermatology” This study found that combined microneedling with minoxidil significantly improved hair count and diameter in patients with androgenetic alopecia compared to minoxidil alone, despite mild adverse events, and microneedling parameters like depth and duration did not significantly affect outcomes.
28 citations
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March 2014 in “International Journal of Nanomedicine” This study developed lipid nanoparticles for delivering minoxidil and finasteride to the dermis and hair follicles, showing stability and a desired prolonged release, though with low skin penetration levels.
December 2023 in “International Journal of Dermatology” This study found an increased risk of asthma and allergic rhinitis in individuals with hidradenitis suppurativa.
January 2024 in “Frontiers in Bioengineering and Biotechnology” In this mouse study, researchers found that nanoparticles loaded with umbilical cord-derived stem cell membranes and minoxidil enhanced hair growth by improving drug solubility and transdermal delivery, increasing VEGF, IGF-1, MKI67, and CTNNB protein levels in skin tissue compared to regular minoxidil.
November 2025 in “Journal of Investigative Dermatology” N,N-Dimethylglycine sodium salt may improve skin health and treat hair loss.
35 citations
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November 2024 in “Gels” This review discusses hydrogel-forming microneedles for non-invasive drug delivery in dermatology and reports no new clinical results, emphasizing their promise in improving treatment adherence and patient comfort.
12 citations
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February 2022 in “Acta Biomaterialia” In this study, researchers found that dissolving microneedles made with hyaluronic acid enhanced the effectiveness of minoxidil in reducing hair loss and promoting hair growth in alopecia-affected mice more effectively than topical minoxidil alone, while using only 10% of the drug amount.
May 2026 in “Journal of the American Academy of Dermatology” This study investigated the effectiveness of combining microneedling with 2% topical minoxidil in women with mild-to-moderate androgenetic alopecia and found that adding microneedling every 2 or 4 weeks did not enhance outcomes compared to using minoxidil alone over 24 weeks.
September 2023 in “Journal of The American Academy of Dermatology” This review evaluates the clinical experience of using low-dose oral minoxidil for treating alopecia and highlights the ongoing concerns about its potential side effects without reporting new clinical results.
February 2023 in “Reactions Weekly” August 2002 in “Inpharma Weekly”
5 citations
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January 2021 in “Journal of The American Academy of Dermatology” This article reflects on the history and significance of the FDA's approval of topical minoxidil for treating androgenetic alopecia in men and women, dating back to 1988 and 1991 respectively.
February 2018 in “The Journal of Sexual Medicine” The researchers reported that using Natesto® testosterone gel improved erectile function and mood in hypogonadal men over a 90-day period.
May 2026 in “Journal on musculoskeletal ultrasound in pain medicine.” In this case study, a 29-year-old male experienced chronic pelvic pain and erectile dysfunction after finasteride use, with no effective relief from pharmacological and procedural interventions, prompting a shift towards pain education and behavioral strategies due to a possible nociplastic pain mechanism.
136 citations
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January 2013 in “International Journal of Trichology” This study found that adding microneedling to minoxidil treatment significantly improved hair growth in men with androgenetic alopecia compared to minoxidil alone across all assessed measures.
April 2018 in “The Journal of Urology” This study found that treatment with imipramine and pseudoephedrine can effectively restore antegrade ejaculation in diabetic patients suffering from retrograde ejaculation, offering potential fertility solutions through natural or assisted reproductive methods.
In this open uncontrolled study on microneedling as an adjuvant therapy for frontal fibrosing alopecia, researchers observed stable frontotemporal recession measurements while patients reported improvements in quality of life and a reduction in inflammatory activity parameters.