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    Glossary Niche

    role of an organism within its ecosystem

    In biology, a niche refers to the role or function of an organism within its ecosystem, including its interactions with other organisms and its environment. For example, in the context of hair biology, the niche of hair follicle stem cells includes their specific location in the skin, the signals they receive from surrounding cells, and their role in hair growth and regeneration.

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    1. Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches Nature Communications · 2012 · 179 citations
    2. Compartmentalized organization: a common and required feature of stem cell niches? Development · 2010 · 63 citations
    3. The Dynamic Duo: Niche/Stem Cell Interdependency Stem Cell Reports · 2015 · 31 citations
    4. Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms Stem Cell Reviews and Reports · 2010 · 13 citations
    5. Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles Health Science Reports · 2022 · 5 citations
    6. Aging of hair follicle stem cells and their niches Journal of Biochemistry and Molecular Biology · 2022 · 2 citations
    7. The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse Stem cell research & therapy · 2022 · 2 citations
    8. Niche work when you can get it: collagen XVII and the melanocyte stem cell Pigment Cell & Melanoma Research · 2011 · 2 citations
    9. A notch above bowl: Specification of niche cells in the Drosophila testis ScholarlyCommons (University of Pennsylvania) · 2011 · 1 citations
    10. Niche-dependent immunometabolic regulation of tissue repair and regeneration Immunity & Inflammation · 2026
    11. From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization Frontiers in Cell and Developmental Biology · 2026
    12. Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair Nature Communications · 2026
    13. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    14. Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies Cell Communication and Signaling · 2026
    15. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations
    16. Stem cell dynamics in the hair follicle niche Seminars in Cell & Developmental Biology · 2013 · 135 citations
    17. Micropatterned dermal–epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis Acta Biomaterialia · 2013 · 65 citations
    18. Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration <i>in vivo</i> The EMBO Journal · 2019 · 44 citations
    19. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018 · 43 citations
    20. The Disturbed Microbial Niches of Itchy Scalp Journal of Cosmetic Dermatology · 2025 · 1 citations
    21. 440 Charting the Spatially Resolved Hair Follicle Stem Cell Niche: A Multi-Omics Atlas of Healthy and Diseased Scalp Journal of Investigative Dermatology · 2025
    22. eLife Assessment: The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling 2025
    23. Immune niches for hair follicle development and homeostasis Frontiers in physiology · 2024
    24. The skin mycobiome and intermicrobial interactions in the cutaneous niche Current opinion in microbiology · 2023
    25. Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche Scientific reports · 2023
    26. Dermal niche signaling and epidermal stem cells Advances in stem cells and their niches · 2019
    27. Cell Enriched Autologous Fat Grafts to Follicular Niche Improves Hair Regrowth in Early Androgenetic Alopecia Aesthetic Surgery Journal · 2020 · 8 citations
    28. Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair Nature Communications · 2023 · 4 citations
    29. Nutritional Niche Construction and Local Adaptation: The Aquatic Resource-Driven Hypothesis of EDAR V370A in East Asia Zenodo (CERN European Organization for Nuclear Research) · 2026
    30. Nutritional Niche Construction and Local Adaptation: The Aquatic Resource-Driven Hypothesis of EDAR V370A in East Asia Zenodo (CERN European Organization for Nuclear Research) · 2026