Neurosteroids help regulate oxytocin levels, especially during stress and pregnancy, to protect against premature labor.
2 citations,
March 2023 in “Experimental neurology” Pregnenolone might help manage movement issues caused by Parkinson's disease treatment without reducing the medicine's effectiveness.
3 citations,
January 2022 in “Journal of neuroendocrinology” Sex hormones affect brain cells differently in males and females.
April 2024 in “Journal of psychiatric research” Short-term finasteride use in male rats caused anxiety, depression, and memory problems.
March 2023 in “Epilepsia” Trilostane may help delay epilepsy development by increasing certain brain chemicals.
16 citations,
November 2018 in “The journal of pain/Journal of pain” 14,15-EET may help reduce poststroke pain by affecting certain brain proteins.
54 citations,
August 2005 in “Alcohol” Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.
65 citations,
October 2008 in “Journal of Neuroendocrinology” 36 citations,
June 2001 in “Neuroscience Letters” Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.
34 citations,
November 2011 in “Alcoholism: Clinical and Experimental Research” Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.
34 citations,
May 2007 in “Neuroscience” Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.
32 citations,
February 2014 in “Psychopharmacology” Dutasteride makes alcohol less sedating and may lead to less drinking in men.
29 citations,
July 2004 in “Pharmacology, Biochemistry and Behavior” Finasteride reduces alcohol withdrawal effects, especially in female mice.
21 citations,
June 2005 in “Alcoholism: Clinical and Experimental Research” Finasteride reduces alcohol withdrawal severity and anxiety in mice, but may increase withdrawal severity in some cases.
5 citations,
October 2020 in “Brain Research Bulletin” Etifoxine, an anxiety drug, can lessen brain inflammation and cognitive issues in mice, partly by increasing production of protective brain steroids.
3 citations,
October 2015 in “Human Psychopharmacology-clinical and Experimental” Finasteride doesn't affect sleep spindles in men.
2 citations,
December 2019 in “Neurobiology of Stress” Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
137 citations,
March 2006 in “Cns Drug Reviews” Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
82 citations,
August 2006 in “Pharmacology, Biochemistry and Behavior” Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.
50 citations,
September 2016 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.
33 citations,
April 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity” 5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.
26 citations,
July 1995 in “Neurobiology of Aging” Finasteride affects prostate weights and pituitary activity differently with age.
25 citations,
June 2017 in “Scientific reports” Stress worsens Tourette symptoms by increasing allopregnanolone levels.
24 citations,
December 2013 in “Sexual medicine reviews” Finasteride can cause sexual problems and depression in young men.
19 citations,
July 2006 in “Physiology & Behavior” Finasteride slows down motherly behavior in first-time pregnant rats.
18 citations,
November 2007 in “Annals of Surgery” Finasteride reduces inflammation and improves immune response after trauma by altering hormone levels.
17 citations,
February 2014 in “The International Journal of Neuropsychopharmacology” 16 citations,
September 2016 in “Neuropharmacology” Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.
15 citations,
May 2007 in “Hormones and Behavior” Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.
12 citations,
April 2018 in “Physiology & Behavior” Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.