50 citations,
June 1993 in “European journal of biochemistry” Intermediate filaments are crucial for cell structure and function, regulated by specific genes and proteins.
70 citations,
January 2014 in “International review of cell and molecular biology” Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
January 2014 in “Springer eBooks” Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” AP-2α and AP-2β proteins are essential for healthy adult skin and hair.
12 citations,
January 2014 in “Cell structure and function” Different combinations of human hair keratins affect how hair fibers form.
4 citations,
February 2020 in “Cell & tissue research/Cell and tissue research” Hair follicle stem cells might help treat traumatic brain injury.
17 citations,
July 2017 in “Molecular and Cellular Endocrinology” Effective treatments for spinal and bulbar muscular atrophy are not yet available; more research is needed.
September 2023 in “Asian journal of beauty & cosmetology” Lipids are important for healthy hair, but their exact role is not fully understood and needs more research.
Type II spiral ganglion neurites avoid high concentrations of laminin and fibronectin.
91 citations,
December 2000 in “The journal of cell biology/The Journal of cell biology” Scientists successfully created mouse hair proteins in the lab, which are stable and similar to natural hair.
238 citations,
October 1994 in “Current opinion in genetics & development” The document concludes that recent research has improved understanding of skin diseases and the balance between cell growth and differentiation in the epidermis.
Meis2 is essential for touch sensation and nerve function in mice.
The transcription factor Meis2 is essential for touch sensation and proper nerve development in touch receptors.
88 citations,
May 2005 in “Journal of Dermatological Science” Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.
9 citations,
May 2021 in “Immunological Reviews” Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.
9 citations,
March 2011 in “Current Pharmaceutical Biotechnology” Stem cell therapies show promise for treating various diseases but face challenges in clinical use and require better monitoring techniques.
5 citations,
January 2017 in “Molecular Medicine Reports” Human hair follicle cells can be turned into neural stem cell-like cells, which might help treat brain diseases.
1533 citations,
October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
165 citations,
October 2013 in “Nature Communications” Scientists made working salivary glands in mice using bioengineered cells, which could help treat dry mouth.
133 citations,
May 2016 in “Cell Host & Microbe” Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.
101 citations,
January 1997 in “Journal of Investigative Dermatology Symposium Proceedings” Nerves and chemicals in the body can affect hair growth and loss.
86 citations,
March 2018 in “ACS Biomaterials Science & Engineering” MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.
84 citations,
June 2013 in “Stem Cells Translational Medicine” New methods for skin and nerve regeneration can improve healing and feeling after burns.
77 citations,
February 2017 in “Stem Cell Reports” SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.
77 citations,
April 2016 in “Science Advances” Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
72 citations,
October 2009 in “The FASEB journal” TRH stimulates human hair growth and extends the hair growth phase.
69 citations,
June 2017 in “Experimental Biology and Medicine” Advanced human skin models improve drug development and could replace animal testing.
48 citations,
June 2014 in “Neurobiology of Disease” The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.
34 citations,
November 2010 in “Development” Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.
31 citations,
November 2016 in “Cell Reports” Touch sensitivity in mouse skin decreases during hair growth due to changes in touch receptors.