April 2026 in “Experimental & Molecular Medicine” This study used integrated single-cell chromatin and transcriptomic analyses in developing mouse skin to uncover gene networks involved in skin lineage specification and identified Mef2c+ upper fibroblasts as potential precursors to certain muscle-like structures, with cross-species findings in human skin.
January 2018 in “Stem cell biology and regenerative medicine” This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.
29 citations
,
June 2015 in “Kidney International” This study developed a kidney-specific knockout mouse model lacking the Flcn gene, which recapitulates human Birt-Hogg-Dubé kidney tumorigenesis and shows that mTOR pathway inhibition with rapamycin can suppress tumor growth.
13 citations
,
March 2012 in “The Journal of Dermatology” This study reports that transplanted mouse hair follicles restored piloerection ability and connected properly with host tissues, suggesting potential for advanced hair restoration therapies.
2 citations
,
March 2019 in “Journal of Histochemistry and Cytochemistry” This study found that NNAT is localized in both undifferentiated and differentiated cells across various rat tissues and has cell-specific intracellular localization, suggesting distinct functional roles.
2 citations
,
May 2017 in “InTech eBooks” This review discusses the regenerative potential of hair follicle stem cell populations and current approaches to reconstructing folliculogenesis for alopecia therapy, but reports no new clinical results.
4 citations
,
October 2025 in “Science Advances” In this study, researchers found that tubular VCAM1 expression in transgenic mice and human kidney transplant biopsies precedes nephron loss and fibrosis, indicating its potential as an early biomarker for tubular fate and adverse kidney outcomes.
1 citations
,
August 2009 in “Mechanisms of Development” 2 citations
,
May 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that fibronectin is crucial for hair follicle stem cell function and regeneration, with its deletion impairing regeneration but restoration by dermal injection of exogenous fibronectin.
This study introduced fibronectin nanogel microneedles (FNG MNs) that demonstrated improved tissue penetration and transdermal delivery, restoring skin homeostasis in a photoaged mouse model and enhancing collagen deposition and angiogenesis in a diabetic wound rat model.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, FOL-026, a peptide based on osteopontin, was shown to promote angiogenesis and stimulate vascular cell proliferation and migration through neuropilin-1, similar to VEGF, suggesting potential therapeutic applications in vascular repair and angiogenesis-related conditions.
68 citations
,
March 2018 in “Biomaterials” This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.
April 2025 in “Journal of Investigative Dermatology” This study found that fibronectin supports hair follicle regeneration by influencing stem cell behavior through integrin-dependent mechanotransduction, highlighting its potential role in epidermal renewal.
May 2025 in “Cermin Dunia Kedokteran” This study highlights that early detection and tailored treatment based on kidney biopsy classification are crucial in managing lupus nephritis to prevent progression to end-stage kidney disease, with a focus on saving nephron cells.
February 2010 in “Journal of The American Academy of Dermatology” The document concludes that using gadolinium-based contrast agents during MRI can be linked to Nephrogenic Systemic Fibrosis in patients with severe kidney disease.
10 citations
,
February 2021 in “PLoS biology” This study found that corin, a protease, plays a crucial role in eccrine sweat glands by promoting sweat and salt excretion, which helps regulate electrolyte balance.
This study found that Wnt7a protein expression increased after corneal epithelial injury and promoted human corneal epithelium cell proliferation by upregulating fibronectin and enhancing cell adhesion.
87 citations
,
January 2017 in “PLoS Genetics” This study found that simultaneously inhibiting both KLK5 and KLK7 proteases completely rescued skin barrier defects in a mouse model of Netherton syndrome, suggesting both should be therapeutic targets.
5 citations
,
June 2024 in “Pharmacological Research” This study identified neuropilin-1 as the receptor for FOL-026 and showed that it stimulates angiogenesis and cell growth, suggesting potential for vascular repair and enhanced angiogenesis therapies.
This article discusses the role of epimorphin as a key morphoregulator for various epithelial cells in tubulogenesis and reports no experimental results on its signaling pathways.
35 citations
,
September 2009 in “Development” This study found that overexpression of the intercellular adhesion protein Necl2 in hair follicle stem cells was associated with reduced cell proliferation and delayed wound healing in both cultured cells and transgenic mice.
December 2024 in “European journal of medical research” This study suggests that the NCSTN knockout mouse could serve as an HS animal model, with tamoxifen potentially used for gene deletion in mice.
60 citations
,
July 2014 in “Autophagy” This study found that autophagy is impaired in Birt-Hogg-Dubé syndrome-associated renal tumors and identified that the FLCN protein interacts with key autophagy components regulated by ULK1.
July 2024 in “Journal of Investigative Dermatology” ATR12-351 ointment safely delivers LEKTI protein to the skin, reducing enzyme activity in Netherton syndrome.
June 2026 in “ACS Nano Medicine” The study presents the development of fibronectin nanogel microneedles (FNG MNs) designed to enhance tissue penetration and transdermal delivery for anti-aging and diabetic wound healing applications. The FNG MNs, with an average size of 82.0 nm, demonstrate excellent stability, cytocompatibility, and cell penetration capabilities. In a photoaged mouse model, these microneedles effectively restore skin homeostasis by normalizing epidermal thickness, reorganizing collagen and elastin fibers, and reducing inflammation and oxidative stress. In a diabetic wound rat model, FNG MNs promote collagen deposition, hair follicle neogenesis, and angiogenesis while reducing Yes-associated protein expression. These findings suggest that FNG MNs could be a promising formulation for various biomedical applications due to their ability to modulate the extracellular matrix, reduce inflammation, and provide antioxidative benefits.
5 citations
,
January 2011 in “Archives de Pédiatrie” This study illustrates the severe neonatal clinical presentation of Netherton syndrome, which can be fatal despite intensive care, highlighting a specific homozygous mutation (c.1431-12G > A) associated with lethal cases.
37 citations
,
December 1995 in “Journal of Cell Science” This study found that nexin 1 mRNA, a potent protease inhibitor, is prevalent in rat follicular papilla cells and may play a role in regulating hair follicular growth.
17 citations
,
August 2015 in “PLoS ONE” This study found that deferiprone significantly reduced dermal fibrosis and skin thickness in mice with chronic kidney disease treated with Omniscan, suggesting iron's role in gadolinium chelate toxicity and nephrogenic systemic fibrosis.
November 2023 in “Global Medical Genetics” This case report describes a 1-month-old male infant with Netherton syndrome, characterized by severe hypernatremia, skin and scalp issues, highlighting the syndrome's complications, including growth retardation and infection risks in early life.
July 2024 in “Journal of Investigative Dermatology” This study found that systemic treatment with DS77754007, a KLK5 inhibitor, improved skin symptoms in a mouse model of Netherton Syndrome more effectively than certain antibody treatments, suggesting KLK5 inhibition as a promising therapeutic approach for this condition.