Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In a mouse model, this study demonstrated that a microneedle patch system using keratin and integrated with MSC-derived exosomes and UK5099 promoted hair regrowth more efficiently than traditional delivery methods.

RNase L suppresses regeneration in mammals.

This study shows that NIPP1 deficiency in mouse epidermis leads to hyperproliferation, hair loss, and chronic skin inflammation, which can be partially alleviated by dexamethasone treatment.

This study found that notch1 signaling is severely impaired in hidradenitis suppurativa patients with or without NCSTN or other gamma-secretase gene mutations, highlighting a canonical defect at the lesional tissue level.

This study developed electrospun nanofibers containing mupirocin for wound treatment, reporting enhanced antibacterial activity, high water absorption, and accelerated wound healing in a rat model, suggesting potential use for severe skin injuries at risk of infection.

In this study, researchers developed a new method for producing dissolving microneedle array patches containing mesoporous silica nanoparticles, successfully confirming nanoparticle deposition and release in both ex vivo and in vivo models.

This study found that the acceleration of endothelial to mesenchymal transition due to loss of Notch signaling led to delayed wound healing and increased scarring in skin wounds.

This study developed an antimicrobial microneedle patch for delivering apoptotic vesicles to treat infected wounds, which was found to effectively reduce bacterial growth and accelerate scarless healing, including the rapid formation of mature hair follicles in just 8 days, a previously unreported early outcome.

This case report describes severe agranulocytosis and alopecia in a Japanese woman after starting azathioprine, highlighting the potential role of NUDT15 genetic screening in preventing adverse reactions to the drug.

This study found that FOXN1 haploinsufficiency is a significant genetic factor causing T cell lymphopenia at birth, linked to reduced thymic function in both humans and mice.

This review discusses the human Nude/SCID phenotype and FOXN1 gene's role in immunological disorders affecting T-cell development but reports no new clinical findings.

Mast cells and VEGF contribute to post-surgery adhesions, and blocking VEGF can reduce these adhesions; also, certain factors affect wound healing and fetal skin heals differently with age.

This study found that C8/144B antibody exclusively binds to the hair follicle bulge and not the epidermal stratum basale, with cytokeratin 19 serving as a key marker of certain basal keratinocytes that decrease with age.

This study reports that a 9-week-old infant with Netherton syndrome showed rapid and sustained symptom improvement, including skin microbiome normalization and developmental progress, after off-label dupilumab treatment, without adverse reactions.

This case report describes the first documented instance of epidermal nevus syndrome caused by a postzygotic KRAS G12C mutation in a three-year-old Japanese girl.

This study found that VEGF-deficient keratinocytes can form tumors using different aneuploidy and signaling patterns, highlighting VEGF's role beyond angiogenesis in tumor cell growth and survival.

This study found that PCL-based nanofiber scaffolds enhanced cell proliferation and extracellular matrix deposition, suggesting they show promise as a cell delivery system for improving skin wound healing.

This study found that increased intracellular expression of thymosin β4 is necessary and sufficient to induce PAI-1 gene expression in endothelial cells, potentially mediated through Ku80 as a novel receptor.

This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.

This study found that GDNF promotes hair formation and skin wound repair by enhancing the self-renewal and differentiation of bulge stem cells in mice.

This study found that in mice, the epidermal microenvironment reverses the oncogenic effects of GNAQQ209L in melanocytes, inhibiting their survival and proliferation through paracrine signals.

This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.

This study found that cepharanthine may be a promising treatment for enterovirus infections, as it offered full protection to mice against lethal EV71 challenges and reduced viral titers and pathology.

This study identified collagen XXII as a novel extracellular matrix protein specifically present at tissue junctions, where it functions as a cell adhesion ligand for skin epithelial cells and fibroblasts.

This study found that a newly identified gene, mK17n, may explain the lack of nail issues in mK17 null mice by compensating for mK17's function in the nail bed.

This study reports that inhibition of Wnt/β-catenin signaling disrupts hemidesmosome organization in keratinocytes by altering the localization of components like plectin and collagen XVII.

This study suggests that basonuclin may act as a tissue-specific transcription factor for ribosomal RNA genes by interacting with the promoter region necessary for high transcription levels in human keratinocytes.

This study found that ectopic expression of Whn in transgenic mice caused impaired differentiation in epidermis and hair follicles, with hair growth defects and severe urinary tract issues leading to hydronephrosis.

This clinical case report presents photographs of a patient with Netherton syndrome, highlighting severe inflammatory vegetative lesions on the pubic area and umbilicus.