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PAI-2 helps in the maturation and protection of hair and nail cells.

Cystatin M/E helps in the final stages of hair and nail formation by controlling certain enzymes.

Nail disorders not caused by infection are common and can look similar, with psoriasis being the most frequent and having specific nail symptoms.

Certain nail conditions can suggest thyroid problems, with different symptoms for underactive (slow, thin nails) and overactive (spoon-shaped, brittle nails) thyroid.

Some nail changes in chilblains can look like lichen planus and may be severe and long-lasting.

Hair and nail cortisol levels can show long-term stress in young males.

Valproic acid can rarely cause reversible nail discoloration.

Patients with graft-versus-host disease often have nail changes related to the nail matrix, with severity not linked to skin condition.

Recent progress has been made in understanding inherited hair and nail disorders.

Hydroxychloroquine effectively treated twenty-nail dystrophy in a patient with alopecia areata.

Early baldness in men may indicate risks for obesity, metabolic syndrome, insulin resistance, and heart disease, similar to women with PCOS. Alopecia areata is often linked with autoimmune diseases and mental health issues. Certain hair disorders are due to genetic issues, and chemotherapy can cause hair loss through specific biological pathways. Iron deficiency's link to hair loss is still disputed.

Not all nail problems are caused by fungus, new allergens are being identified, PCOS has various treatments, and aesthetic procedures like Botox are advancing.

Cynatine HNS improves hair and nail quality in 90 days.

Many hospitalized children with COVID-19 had skin, mouth, or nail changes, with skin rashes being common.

Instagram ads for skin, hair, and nail supplements often make broad health claims without clear ingredient information, and are not FDA-regulated.

Chemotherapy often causes skin, nail, and hair side effects, significantly impacting quality of life.

Chemotherapy often causes hair loss, nail changes, and mouth issues, but these are usually manageable.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

Eating too much selenium can cause bad breath, hair loss, and nail changes, with harmful effects starting at low daily doses.

Skin changes like hair loss, white patches, and nail changes are common in children after bone marrow transplants, often linked to chronic rejection.

Hair splitting and nail detachment are linked conditions.

Early diagnosis and treatment of nail and skin conditions can improve health and appearance.

A woman's hair loss was caused by her husband's testosterone gel and a diabetic man's nail disease led to bone infection, both treated successfully.

COVID-19 can cause hair loss and nail issues, with treatments available for these conditions.

The LustrivaTM BH-002 supplement and hair serum improved women's hair, skin, and nail health and appearance.

A man had nail and hair changes months after severe Covid-19, showing long-term effects.

Hair and nail conditions can stabilize or improve over time, and new treatments show promise.

Doctors should recognize various nail disorders, new allergens, and metabolic syndrome in patients, and use botulinum toxin carefully in aesthetic procedures.

A test for nail fungus was most accurate with PAS stain, low-dose spironolactone helped two-thirds of acne patients, metformin reduced symptoms of HIV-related fat distribution changes with some side effects, and skin examination with dermoscopy was better at detecting abnormal moles, while temporary tattoos can cause skin reactions.