TLDR Skin changes like hair loss, white patches, and nail changes are common in children after bone marrow transplants, often linked to chronic rejection.
The document summarizes a study that investigated non-malignant late cutaneous changes in 85 children after allogeneic hematopoietic stem cell transplant (HSCT). The study found that 25% of patients experienced alopecia, 14% had vitiligo, 16% had psoriasis/sebopsoriasis, and 6% had nail changes. Chronic graft-versus-host disease (cGVHD) was a significant risk factor for vitiligo, alopecia, and nail changes. Alopecia was also associated with busulfan conditioning and a family history of early male pattern baldness. The study concluded that these cutaneous changes are common after HSCT in children, with cGVHD being a major risk factor, and highlighted the importance of early detection and management to mitigate the psychosocial impact. The study's cross-sectional design may limit the generalizability of the findings, and the associations between vitiligo, psoriasis/sebopsoriasis, and certain risk factors were not analyzed due to a lack of established associations in the literature.
16 citations,
March 2017 in “Bone Marrow Transplantation” Some children who had stem cell transplants developed permanent hair loss, especially when treated with a drug called busulphan.
17 citations,
June 2016 in “Croatian Medical Journal” Patients with chronic graft-versus-host disease often have skin problems like vitiligo and alopecia areata.
27 citations,
September 2014 in “JAMA dermatology” Female donor to male recipient sex mismatch and positive ACA-IgG are key risk factors for vitiligo and alopecia areata in chronic GvHD patients.
2 citations,
January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
October 2023 in “Journal of Medicine, University of Santo Tomas (JMUST Online)” Elderly patients frequently suffer from skin conditions, especially inflammatory ones, highlighting the need for better healthcare.
2 citations,
July 1998 in “Dermatologic Clinics” European dermatologic treatments focus on lifestyle and psychosocial factors, use diverse methods like baths and climate therapy, and emphasize the importance of diet and supplements for skin health.
26 citations,
March 2014 in “Journal of cutaneous medicine and surgery” Topical vitamin D is useful for some skin conditions but not effective for others, and more research is needed.
1 citations,
January 2023 in “Revista Da Associacao Medica Brasileira” People with seborrheic dermatitis often have lower vitamin D levels.
