Non-Malignant Late Cutaneous Changes After Allogeneic Hematopoietic Stem Cell Transplant in Children

    March 2018 in “ Journal of The American Academy of Dermatology ”
    Jennifer T. Huang, James Song, Elena B. Hawryluk, Wendy B. London, Deliang Guo, Makuteswaran Sridharan, David E. Fisher, Leslie Lehmann, Christine Duncan
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    TLDR Skin changes like hair loss, white patches, and nail changes are common in children after bone marrow transplants, often linked to chronic rejection.
    The document summarizes a study that investigated non-malignant late cutaneous changes in 85 children after allogeneic hematopoietic stem cell transplant (HSCT). The study found that 25% of patients experienced alopecia, 14% had vitiligo, 16% had psoriasis/sebopsoriasis, and 6% had nail changes. Chronic graft-versus-host disease (cGVHD) was a significant risk factor for vitiligo, alopecia, and nail changes. Alopecia was also associated with busulfan conditioning and a family history of early male pattern baldness. The study concluded that these cutaneous changes are common after HSCT in children, with cGVHD being a major risk factor, and highlighted the importance of early detection and management to mitigate the psychosocial impact. The study's cross-sectional design may limit the generalizability of the findings, and the associations between vitiligo, psoriasis/sebopsoriasis, and certain risk factors were not analyzed due to a lack of established associations in the literature.
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