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Two new mutations in the AR gene linked to severe androgen insensitivity were found.

A baby with a skin condition improved with treatment but developed a rare form of the condition affecting only his trunk.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

The review shows that skin symptoms like chronic fungal infections, hair loss, and skin depigmentation are key for early detection and management of APECED.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

Frizzled receptors are essential for various body development processes and maintaining certain body functions.

Hairless protein can block vitamin D activation in skin cells.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

Cetaceans lost hair due to changes in the Hr and FGF5 genes.

Deleting MED1 in skin cells causes hair loss and skin changes.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

Biotin deficiency is not a major cause of Telogen Effluvium hair loss.

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

Modern skin cancer treatments can cause skin side effects and hair loss, affecting patients' quality of life.

The document concludes that DNA methylation and the mTOR pathway are important for stem cell function and could impact disease treatment.

Intralesional chemotherapy with 5-fluorouracil and methotrexate may worsen keratoacanthoma-type skin cancer in transplant patients.

The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.

FOL-005, a hair growth promoter, acts locally on mouse skin where injected and could be a promising hair loss treatment.

Higher levels of nidogen1 and type IV collagen are found in basal cell carcinoma compared to normal skin.

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

Identified genes linked to male-pattern baldness may help develop new treatments.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

Researchers found genetic mutations causing hypohidrotic ectodermal dysplasia in 88% of studied patients and identified new mutations and genetic variations affecting the disease.

New techniques have enhanced our understanding of how stem cells function and the role of mutations in aging tissues, which may influence future cancer therapies.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.