A Preview of Selected Articles on DNA Methylation and mTOR Signaling Pathways in Stem Cell Function and Differentiation

    October 2020 in “ Stem cells ”
    Stuart P. Atkinson
    TLDR The document concludes that DNA methylation and the mTOR pathway are important for stem cell function and could impact disease treatment.
    The document reviewed several studies on DNA methylation and mTOR signaling pathways, highlighting their roles in stem cell function and differentiation. Key findings included DNMT3B deficiency in human embryonic stem cells leading to metabolic changes and increased neuronal differentiation, stage-specific effects of mTOR inhibition on erythropoiesis, and the retention of epigenetic memory in iPSCs from polycystic kidney disease patients. Additionally, mTOR signaling was linked to the metabolic reconfiguration necessary for mesenchymal stem cells to adopt an immunosuppressive phenotype, underscoring the intricate connections between epigenetic modifications, metabolic pathways, and stem cell behavior.
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