research Steroidomics for highlighting novel serum biomarkers of testosterone doping
This study found that monitoring endogenous steroid metabolites in serum may improve the detection of testosterone doping by highlighting promising biomarkers.
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450-480 / 1000+ resultsresearch Protein Microarrays
This essay reviews the potential of protein microarrays in proteomics and diagnostics, highlighting no new clinical results but emphasizing the need for advanced high-quality proteins and antibodies.
research scMC learns biological variation through the alignment of multiple single-cell genomics datasets
This study presents a new method called scMC that effectively distinguishes biological from technical variation in single-cell genomics datasets, demonstrating its ability to accurately align and detect biological signals across various experiments.
research LC-APCI+-MS/MS method for the analysis of ten hormones and two endocannabinoids in plasma and hair from the mice with different gut microbiota
This study using high-performance liquid chromatography reported that mice with more diverse gut microbiota had higher levels of specific compounds in hair compared to those with less diversity, with stress affecting certain plasma levels.
research Label-free multiphoton imaging to assess neoadjuvant therapy responses in breast carcinoma
This study explored the use of multiphoton microscopy to monitor changes in tumors and surrounding tissues in breast cancer patients undergoing neoadjuvant chemotherapy, finding it may effectively detect treatment response at cellular levels without using exogenous contrast agents.
research Transcriptomic profiling of Arabidopsis Thaliana responses to Stutzerimonas stutzeri, chlorella vulgaris, and mixed consortium inoculation under salt stress
research Transforming 300 billion points of data into diagnostics, therapeutics and new insights into disease
This review discusses Dr. Atul Butte's lecture on transforming vast data sets into drug discovery insights and highlights the importance of merging clinical, molecular, and environmental data for personalized medicine, but it reports no new clinical results.
research Demonstrating the potential of untargeted hair proteomics for personalized biomarkers in stress-associated disorders
This study found that hair proteomics may serve as a promising, non-invasive biomarker source for stress-associated psychopathology, showing high accuracy in distinguishing patients with non-suicidal self-injury disorder from healthy controls.
research scINSIGHT for interpreting single-cell gene expression from biologically heterogeneous data
This study introduces scINSIGHT, a method to analyze single-cell RNA sequencing data that outperforms existing techniques in identifying gene expression patterns across different biological conditions.
research Profiling of hair proteome revealed individual demographics
In this study, researchers used proteomics to analyze hair samples from diverse ethnic populations, finding that hair protein profiles could potentially distinguish individuals based on ethnicity, sex, and age, offering a new method for human identification in forensic science.
research Multidimensional Profiling of Human Body Hairs Using Qualitative and Semi-Quantitative Approaches with SR-XRF, ATR-FTIR, DSC, and SEM-EDX
This study explored a multidimensional approach to examine body hairs' physico-chemical properties, potentially supporting their use over scalp hairs in forensic and intoxication studies.
research Optimal processing for proteomic genotyping of single human hairs
This study found that optimizing proteomic genotyping conditions from single human hair samples significantly improves the detection of genetically variant peptides, enhancing human identification with high precision across different biogeographic backgrounds.
research Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
This review highlights the inadequacy of the "specificity paradigm" in drug design for complex diseases like Alzheimer's and cancer, suggesting a shift toward developing multitarget drugs to improve treatment efficacy by interacting with multiple targets through various mechanisms.
research Global gene expression and comparison between multiple populations in the mouse epidermis
This study found that a multicolor panel of four surface markers can identify new stem cell populations in mouse hair follicles, providing insights into stem cell diversity and gene expression discrepancies during tissue culture.
research iPrimer-seq: A Streamlined and Cost-Effective Early-Barcoding 3'-End Rna-Seq Method for Transcriptome Profiling from Limiting Cell Inputs
research Human hair follicle transcriptome profiling: a minimally invasive tool to assess molecular adaptations upon low‐volume, high‐intensity interval training
In this study, hair follicle transcriptomic responses to a 10-day HIIT program revealed both existing and new biomarkers, such as certain miRNAs, offering a potentially effective way to monitor cellular and molecular HIIT adaptations.
research Proteomic analysis of hair shaft and nail plate.
This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.
research Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics
This review discusses advancements and gaps in using proteomics for hair testing and its potential in developing a medical proteome repository, but reports no new research findings.
research Long-Term Intravital Imaging of the Cornea, Skin, and Hair Follicle by Multiphoton Microscope
In this study, researchers showed that multiphoton microscopy with fluorescent protein tagging enables single-cell imaging and tracking in live transgenic mice, offering new insights into cell dynamics in stem cell research compared to traditional histological methods.
research COMPATIBILITY OF BIOMAGNETIC PROFILES FOUND IN LIVING MATTER BY CROSS SPECIES DEMONSTRATION
This review discusses the history and evolution of techniques for detecting bioelectromagnetic emissions from living tissues, exploring potential medical applications, but does not present new experimental results.
research Leveraging Single Nucleotide Polymorphism Profiling for Precision Skin Care: How SNPs Shape Individual Responses in Cosmetic Dermatology
In this study, the integration of AI-driven SNP profiling and epigenetic insights in cosmetic dermatology was highlighted as a key development toward personalized skincare, potentially improving treatment effectiveness and reducing side effects.
research 144 Evaluation of contamination and quantification of drug penetrations studies using Quantitative Mass Spectrometry Imaging
QMSI effectively maps and quantifies drug distribution in skin tissues.
research MEGA PROTAC, MEGA DOCK-based PROTAC mediated ternary complex formation pipeline with sequential filtering and rank aggregation
This study found that MEGA PROTAC improved the prediction of ternary structures with higher maximum DockQ scores compared to the BOTCP method in 16 out of 22 test cases.
research Multimodal Non-Invasive Skin Imaging in Dermatology: Current Modalities, Clinical Applications, and Future Integration
This review outlines the key principles and clinical applications of multimodal non-invasive skin imaging technologies, emphasizing their combined strengths in enhancing diagnosis and treatment assessment in dermatology.
research Metabolomic and lipidomic atlas of human hair across its length
The researchers reported creating a Human Hair Atlas that maps over 1200 molecular species in hair, revealing up to 50% variation in metabolite and lipid levels along the hair's length, and identified 122 exposome-related compounds from personal care products.
research Phenotyping mice with skin, hair, or nail abnormalities: A systematic approach and methodologies from simple to complex
This article outlines methods to study the skin and its molecular traits, focusing on interpretation and techniques applicable to mouse models, including diverse assays and approaches like electron microscopy and large-scale lipid analyses.
research A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease
This study developed a 3D ovarian cancer model using microtumours, which effectively mimics minimal residual disease and supports the identification of new drug targets like perhexiline for treatment-resistant cells.
research Proteomic tools for the investigation of human hair structural proteins and evidence of weakness sites on hair keratin coil segments
This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.
research A Powerful Method for Pleiotropic Analysis under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate Cancer
This study introduced a statistical method, PLACO, which revealed novel genetic regions associated with both Type 2 Diabetes and Prostate Cancer from GWAS data.
research Engineering molecular imaging strategies for regenerative medicine
This review discusses regenerative medicine and explores the potential of molecular imaging in enhancing personalized therapies, but it reports no new research results.