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research PRX102 Participates in Root Hairs Tip Growth of Rice
This study found that PRX102, a peroxidase with a unique polar localization pattern, plays a role in root hair growth by aiding the transport of materials to the tips of growing root hairs.
research MG53 Mitigates Nitrogen Mustard-Induced Skin Injury
This study found that topical application of recombinant human MG53 protein mitigated nitrogen mustard-induced skin injuries in mice by preserving epidermal integrity and hair follicle structure.
research Synergistic effect of microneedle-delivered extracellular matrix compound and radiofrequency on rejuvenation of periorbital wrinkles
In this study, the combination of ECM-C with microneedle and radiofrequency treatments improved periorbital wrinkles, skin elasticity, and thickness more effectively than ECM-C with microneedles alone, but subjective evaluations showed no significant differences.
research Radiofrequency treatment induces fibroblast growth factor 2 expression and subsequently promotes neocollagenesis and neoangiogenesis in the skin tissue
This study found that radiofrequency treatment, with or without hydrolyzed collagen, increased dermis thickness, neocollagenesis, and FGF2 overexpression in rat skin tissue.
research The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?
This review discusses the role of the mineralocorticoid receptor in skin biology, highlighting its potential involvement in keratinocyte and hair physiology, and proposes it may affect the side effects of glucocorticoid use.
research MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation
This study found that upregulated miR-149 restricted hair follicle stem cell differentiation and hair growth by inhibiting the MAPK1/ERK2 pathway, which affects FGF2 and c-MYC expression.
research Profibrotic Molecules Are Reduced in CRISPR-Edited Emery–Dreifuss Muscular Dystrophy Fibroblasts
This study found that fibroblasts from Emery-Dreifuss muscular dystrophy patients with certain genetic mutations overexpress markers of fibrosis, and gene correction techniques reduced fibrogenic molecule expression in cell models, suggesting potential therapeutic applications.
research A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia
This study found that while MK-0773 significantly increased lean body mass in sarcopenic frail elderly women, it did not significantly improve muscle strength or physical function compared to placebo.
research A novel calmodulin‐interacting Domain of Unknown Function 506 protein represses root hair elongation in Arabidopsis
In this study, the authors reported that AtRXR3, a phosphorus-inducible DUF506 protein, modulates root hair growth under phosphorus stress by interacting with calmodulin and influencing calcium oscillations.
research The efficacy in treatment of facial atrophic acne scars in Asians with a fractional radiofrequency microneedle system
This study found that fractional radiofrequency microneedle treatment was safe and effective for improving acne scars in Asians, with minimal adverse effects reported at 6-month follow-up.
research Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation
mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.
research AB032. Development of new treatment modality for male infertility by using phytopharmaceuticals
This study explored the effects of MOTILIPERM on infertility in a rat model with varicocele and oxidative stress, reporting its potential therapeutic efficacy.
research Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease?
This article proposes using the hallmarks of ageing and dysregulated microRNAs to create a molecular morbidity score that could improve prognostication and clinical trial inclusion for patients with multimorbidity.
research Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling
This study develops FR-1, a topical small molecule, which reduces scarring and avoids skin atrophy in a murine wound model, showing potential for treating fibrosis without the side effects of current therapies.
research The mouse frizzy (fr) and rat ‘hairless’ (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8)
This study concluded that the frizzy mutation in mice is linked to a T to A transversion in Prss8 and is orthologous to the 'hairless' mutation in rats.
research Film-trigger applicator (FTA) for improved skin penetration of microneedle using punching force of carboxymethyl cellulose film acting as a microneedle applicator
This study found that the film-trigger applicator system enhanced drug delivery efficiency and skin penetration of dissolving microneedles compared to traditional patch systems in both lab and animal models.
research Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats
In this study, Nrf-2-expressing hair follicle mesenchymal stem cells showed the most significant therapeutic effect in a rat model of ulcerative colitis, suggesting a new potential treatment for the disease.
research Melandrium firmumExtract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice
This preliminary study found that Melandrium firmum extract may promote hair growth and inhibit 5α-reductase, suggesting potential as a candidate for treating androgenetic alopecia.
research NMR Study on Finasteride
This study used NMR spectroscopy and other techniques to fully assign the proton and 13C spectra of the 5α-reductase inhibitor finasteride.
research 869 The specification of Merkel cell in the back skin and glabrous paw skin is controlled by FGFR2-meditated signaling
This study found that, in mice, different precursor populations give rise to Merkel cells in hairy versus glabrous skin, but their formation is controlled by a common genetic program involving FGFR2 signaling.
research The Growth Factors in Advanced Platelet-Rich Fibrin (A-PRF) Reduce Postoperative Complications after Mandibular Third Molar Odontectomy
This study found that advanced platelet-rich fibrin (A-PRF) reduced postoperative complications like pain, trismus, and edema following mandibular wisdom teeth removal.
research miR‐124 promotes neural differentiation in mouse bulge stem cells by repressing Ptbp1 and Sox9
This study found that miR-124 may facilitate the differentiation of hair follicle stem cells into neuronal cells by targeting Sox9 and Ptbp1.
research 645 MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma
This study found that in mutant NRAS melanoma, MEK inhibitors led to increased AKT signaling and reduced MIG6, a change that may enhance cell migration and invasiveness.
research MIL-88A derived zerovalent iron embedded mesoporous carbon with carbon black composite based electrochemical sensor for the detection of metol
This study reported that the Fe@C/CB electrocatalyst effectively detected Metol in water samples with a low detection limit, high sensitivity, and good stability, suggesting it as a promising tool for environmental monitoring.
research MicroRNA 조절을 통한 상처 치유 기전에 관한 연구
This study suggests that PDRN may enhance wound healing by reducing MIR135b expression, which in turn increases FOXO1 expression in keratinocytes.
research Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene
This study found that formulating raloxifene in nano-lipid carriers significantly enhanced its permeation and cytotoxicity against cancer cells compared to raw raloxifene.
research Designing a Placebo Microneedle Stamp: Modeling and Validation in a Clinical Control Trial
This study demonstrated that while the proposed placebo microneedle stamp design was partially successful in blinding participants with low skin sensitivity, further development of suitable placebo controls is needed.
research Exploring lncRNA-Mediated Mechanisms in Muscle Regulation and Their Implications for Duchenne Muscular Dystrophy
This review compiles current research on the role of long non-coding RNAs in regulating muscle growth and regeneration processes, particularly their influence on Duchenne muscular dystrophy, and reports no new clinical results.
research Morgellon's syndrome. Evidence of a microorganism causing an unexplained dermopathy
This book critiques Dr. Conroy's theory on Morgellon's disease, highlighting a lack of scientific evidence and detailing his unverified claims about fungal organisms attracted to cocaine.