65 citations,
July 2006 in “Journal of biological chemistry/The Journal of biological chemistry” The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.
52 citations,
December 2014 in “Journal of Dermatological Science” Apremilast may help treat hair loss in alopecia areata.
46 citations,
May 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Significant progress was made in understanding PXE, but effective treatments are still needed.
25 citations,
June 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” VDR regulation varies by tissue and is crucial for its biological functions.
24 citations,
February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Two new proteins, hKAP1.6 and hKAP1.7, are found in the hair follicle cortex.
20 citations,
April 2000 in “Experimental dermatology” ODC transgenic mice can model human hair loss with skin lesions.
17 citations,
July 1994 in “Journal of Dermatological Science” The cause of alopecia areata is likely a mix of genetics, immune system issues, and environmental factors, with more research needed to understand it fully.
15 citations,
March 2015 in “Experimental Dermatology” Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
14 citations,
September 2018 in “Biochemical and Biophysical Research Communications” Growing hair cells with dermal cells can potentially treat hair loss.
13 citations,
February 2018 in “Plastic and Reconstructive Surgery” The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.
6 citations,
February 2013 in “Journal of Visualized Experiments” The method quickly analyzes hair growth genes and shows that blocking Smo in skin cells stops hair growth.
5 citations,
February 2010 in “Drug development and industrial pharmacy” Vesicles made of behenyltrimethylammonium chloride and stearic acid can triple the skin absorption of hinokitiol, which may help with hair growth.
4 citations,
February 2018 in “Journal of Investigative Dermatology” The document concludes that a protein involved in hair growth may link to baldness and that more research is needed on its role in hair loss and skin cancer treatments.
2 citations,
February 2023 in “Transgenic Research” The E2 protein affects gene activity in hair follicles of mice.
1 citations,
February 2017 in “Dermatologic Surgery” The basement membrane matrix helps rebuild hair follicles faster and more effectively.
CaBP1 and CaBP2 are important for maintaining hearing by supporting continuous calcium currents and nerve signaling in the ear.
January 2024 in “ACS Biomaterials Science & Engineering” A new method using a microfluidic device can prepare hair follicle germs efficiently for potential use in hair loss treatments.
December 2023 in “Redox biology” The substance DMC helps get rid of aging cells by triggering a process that causes cell death, which could treat age-related diseases.
November 2023 in “npj regenerative medicine” Skin spheroids with both outer and inner layers are key for regrowing skin patterns and hair.
February 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Merkel cells stabilize nerve endings in the skin, and they change independently of each other.
Different types of sun exposure can damage skin cells and affect healing, with chronic exposure being more harmful, and certain immune cells help in the repair process.
March 2021 in “Cell stem cell” Skin cell behavior is influenced by the tightness of nearby cells, affecting their growth and development.
April 2018 in “Journal of Investigative Dermatology” Removing STAT5 from 3D-cultured human skin cells reduces their ability to grow hair.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” Activating Sonic Hedgehog signaling in cancer stroma may help treat basal cell carcinoma.
April 2016 in “Journal of Investigative Dermatology” A specific type of immune cells, called CD301b-expressing macrophages, are crucial for skin repair processes.
January 2023 in “Pharmaceutics” AA–TF#15 significantly promotes hair regrowth and could be an effective treatment for androgenic alopecia.
October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Scientists used a special imaging technique to observe that hair follicle regeneration involves cell division and structural changes, mostly in the lower part of the follicle, and that the dermal papilla at the base is crucial for regrowth.
578 citations,
April 1993 in “Cell” TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.
184 citations,
February 2015 in “EBioMedicine” A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.
71 citations,
January 1998 in “Pathobiology” The document concludes that certain rats and mice are useful for studying hair loss in humans and testing treatments.