research Keratinocyte Stem Cells: Role in Aging
Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.
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research The Role of Macrophages in Skin Homeostasis
Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.
research Roles of Wnt7a in Embryo Development, Tissue Homeostasis, and Human Diseases
Wnt7a protein is crucial for development and tissue maintenance and plays varying roles in diseases and potential treatments.
research The Biology of Hair Growth
Hair growth is influenced by hormones and goes through different phases; androgens can both promote and inhibit hair growth depending on the body area.
research Lipid Signaling in Keratinocytes: Lipin-1 Plays a Part
Lipin-1 is important for skin cell differentiation and skin barrier function.
research Obesity and Wound Healing: Focus on Mesenchymal Stem Cells
Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.
research Catalytic-Dependent and -Independent Activities of Polycomb Repressive Complex 1 Differentially Regulate Skin Stem Cell Specification
PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.
research Hair Follicle Bulb Developed as 3D Scaffold-Free Microtissue
Scientists created a tiny, 3D model of a hair follicle that grows and acts like a real one.
research Foxp3 Post-Translational Modifications and Treg Suppressive Activity
Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.
research Lamins in Development, Tissue Maintenance, and Stress
Lamins are vital for cell survival, organ development, and preventing premature aging.
research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis
The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.
research Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, Lower Self-Esteem, and Lower Quality of Life
People with Lichen Planopilaris tend to be more depressed, have lower self-esteem, and a worse quality of life.
research Heme Oxygenase and the Skin in Health and Disease
HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.
research Epidermal Stem Cells: An Update on Their Potential in Regenerative Medicine
Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.
research Characterization of a Mouse Scube3 Reporter Line
Mouse Scube3 affects teeth, tongue, vibrissae, and eye development, but not facial structure or limb growth.
research Runx Family Genes in Tissue Stem Cell Dynamics
Runx genes are important for stem cell regulation and their roles in aging and disease need more research.
research FLCN Regulates Transferrin Receptor 1 Transport and Iron Homeostasis
FLCN helps control iron levels in cells.
research Ton1 Recruiting Motif 21 Positively Regulates the Flavonoid Metabolic Pathway at the Translational Level in Arabidopsis Thaliana
TRM21 helps control flavonoid production and root hair growth in Arabidopsis thaliana.
research Syndactyly Type III and Hypotrichosis in Oculodentodigital Syndrome with GJA1 Mutation
A boy with Oculodentodigital syndrome had a unique GJA1 gene mutation causing his symptoms.
research Dipeptidyl-Peptidase 4 (DPP4)-Positive Fibroblasts Are Responsible for Secretion of Pro-Fibrotic Matrix Proteins in Human Skin
DPP4-positive fibroblasts play a major role in producing proteins that lead to skin fibrosis.
research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
research Fibroblast Heterogeneity: Implications for Human Disease
Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
research Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ
Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.
research Roles of Jumonji and Jumonji Family Genes in Chromatin Regulation and Development
Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.
research Quantitative Single-Cell Approaches to Stem Cell Research
New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.
research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis
Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
research Melanocytes: The New Black
Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.
research Clinical and Biological Impact of the Exposome on the Skin
Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.
research SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells
SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.
research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion
The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.