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840-870 / 1000+ resultsresearch Differential cold stress intensities drive unique morphological and transcriptomic changes in Zea mays root hairs
This study found that maize root hairs respond differently to cold stress based on severity, with mild cold allowing limited growth through adaptive remodeling, while severe cold causes more pronounced inhibition and prioritizes stress defense, affecting transcriptome and morphology.
research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
In this study, severe hair loss occurred in PKC epsilon transgenic mice treated with DFMO during skin tumor prevention, highlighting a link between polyamine biosynthesis, hair follicle maintenance, and metastasis suppression.
research The disrupted balance between hair follicles and sebaceous glands inHoxc13‐ablated rabbits
This study found that Hoxc13-/- rabbits exhibit complete hair loss on the head and dorsum, providing a potential model for understanding human ECTD-9 and related dermatological conditions.
research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia
This study found that overexpression of the mineralocorticoid receptor in a mouse model led to premature epidermal barrier development, keratinocyte apoptosis, and postnatal alopecia, indicating new roles for MR signaling in skin physiology.
research The Antioxidant Activities and Hair-growth Promotion Effects of Tenebrio molitor Larvae Extracts (TMEs)
This study investigates the effects of Tenebrio molitor as a novel biomaterial for preventing alopecia and promoting hair growth, but reports no conclusive results.
research An Unusual Cause of Primary Amenorrhea
In this case report, an 18-year-old Vietnamese female with primary amenorrhea and normal female phenotype was most likely diagnosed with müllerian agenesis, highlighting its association with embryologic underdevelopment of the müllerian duct.
research Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding
This study identified a recurrent mutation in the endothelin receptor type A associated with mandibulofacial dysostosis with alopecia, and proposed a mechanism involving increased ligand affinity due to structural changes.
research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation
This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.
research Additional file 8 of Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus
Melatonin affects when and how certain genes work during the growth of goat hair follicles.
research Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin
This study presents a two-photon imaging method to visualize low-threshold mechanoreceptor axon terminals in live mouse forepaw skin, enabling repeated high-resolution imaging to study sensory circuits during development and adulthood.
research Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits
In this study, researchers identified thousands of mRNA, lncRNA, circRNA, and miRNA transcripts involved in different hair follicle stages of Rex rabbits and highlighted significant gene expression changes and pathway enrichments, providing insights into the regulatory mechanisms of hair development in these animals.
research The G60S Connexin43 Mutant Regulates Hair Growth and Hair Fiber Morphology in a Mouse Model of Human Oculodentodigital Dysplasia
This study observed that mice with a Cx43 mutation exhibited slower and asynchronous hair regrowth with severe cuticle weathering, mimicking aspects of hair phenotype in some ODDD patients.
research Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice
A gene mutation in mice causes increased mast cells and disorganized hair follicles in their skin.
research Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus
This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.
research Human hair morphology: a scanning electron microscopy study on a male Caucasoid and a computerized classification of regional differences.
This study examined the morphological variations of terminal hair from different body regions of a Caucasian male, finding notable differences in diameter and features like "steak-boning" in specific hair types.
research The Endocrine control of fibre growth and shedding in cashmere goats
This article reviews how photoperiod, melatonin, and prolactin influence moult timing in mammals, focusing on cashmere goats, but reports no new experimental findings.
research Reproductive seasonality and maturation throughout the complete life-cycle in the mouflon ram (Ovis musimon)
This study found that in captive mouflon rams, reproductive and physical maturation, marked by changes in hormone levels and physical attributes, progresses gradually across their life span, with sexual maturity tied closely to physical maturity.
research Defective trophoblast function in mice with a targeted mutation of Ets2
Ets2 gene is crucial for placental development in mice.
research Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles
The Dfl mutation in mice causes poor sebaceous gland function and complete hair loss.
research De novo variation in ARID1B gene causes Coffin-Siris syndrome 1 in a Chinese family with excessive early-onset high myopia
This study is the first to identify a de novo heterozygous frameshift insertion variant in the ARID1B gene as a cause of Coffin-Siris syndrome with an association to excessive early-onset high myopia.
research Management of Post-Acne Scarring
Various treatments can improve post-acne scars, but results vary.
research Vitamin D and skin diseases: A review
This review discusses the various roles of vitamin D in skin disorders, including established use in psoriasis and potential applications for atopic dermatitis and skin cancer prevention, but reports no new clinical results.
research Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90
This study reports that in systemic sclerosis, CD34+ dermal fibroblasts transition to CD34−, podoplanin+, and CD90+ fibroblasts across the dermis, suggesting a role in unchecked fibrosis.
research Chronic graft versus host disease and skin
This article reviews the clinical aspects and potential mechanisms of chronic graft vs host disease skin manifestations, describing a novel form of premature skin aging, but presents no new research findings.
research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease
This review discusses the roles and mechanisms of tissue-resident regulatory T cells in immune regulation and tissue homeostasis, but reports no new experimental results.
research Review of systemic methotrexate therapy in pediatric dermatoses
This review discusses the use of methotrexate for pediatric dermatoses and reports increased use in certain conditions like psoriasis, but mainly isolated case reports for others.
research Medical Dermatology
Early diagnosis, innovative treatments, and considering systemic conditions are crucial in dermatological care.
research The expanding impact of T-regs in the skin
This article reviews the emerging non-inflammatory roles of regulatory T cells in the skin and reports no new clinical findings, suggesting broad biological influence beyond traditional immune functions.
research Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers
This review explores the role of Tregs in autoimmune skin diseases, transplantation, and skin cancer, and discusses Tregs-based therapies' potential for treating autoimmunity without reporting new experimental results.