Chronic Graft Versus Host Disease and Skin

August 2003 in “ Journal of the European Academy of Dermatology and Venereology ”

Michele Fimiani, G. De Aloe, Aldo Cuccia

chronic graft versus host disease cGVHD collagen fibrosis pigmentation disorders alopecia autoantibodies

TLDR cGVHD often severely affects the skin, causing rapid aging and other issues.

The document discussed chronic graft versus host disease (cGVHD) and its significant impact on the skin, highlighting a study by Selvaag et al. that observed rapid facial skin aging in two young patients, linked to autoantibodies against collagen. cGVHD affected 30-50% of bone marrow and stem cell transplant patients, with skin involvement in over 80%. It caused fibrosis, pigmentation disorders, alopecia, and increased risk of infections and malignancies. The study emphasized the importance of understanding cGVHD's dermatological manifestations due to its complex immunological interactions and severe complications.

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