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AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

A mother and son both had ulcerative colitis and alopecia, suggesting a genetic link in autoimmune disorders and successful treatment with cyclosporine.

The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.

Oral contraceptives lower testosterone levels in women, especially those with certain genetic traits, and may be linked to increased breast cancer risk.

Scientists developed a method to grow human fetal skin and digits in a lab for 3-4 weeks, which could help study skin features and understand genetic interactions in tissue formation.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

Merremia peltata leaf extract, particularly the bufotalinin compound, shows potential for treating hair loss.

Scopolin and scopoletin from Merremia peltata leaves may help treat hair loss and showed promising results in rabbit tests.

More research is needed to understand the genetic causes of Alopecia areata to develop better treatments.

Rabbits lacking the Hoxc13 gene show similar hair and skin issues to humans with ECTD-9, making them good for research on this condition.

MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.

Certain genetic markers linked to wool quality in Rambouillet sheep were identified, which can guide better breeding choices.

Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.

Certain genes may influence hair loss differently in men and women.

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

Auto-antibody testing is a useful but not definitive tool in diagnosing interstitial lung diseases, and using a specific algorithm could make testing more cost-effective.

Human hair follicles may provide a noninvasive way to diagnose diseases and have potential in regenerative medicine.

Avoiding dyed wigs and clothing improved severe allergic reactions in a woman treated with diphencyprone.

Hair diameter and curvature are mostly determined by genetics.

Heredity and hormones cause common hair loss, and topical minoxidil is the first recommended treatment.

Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.

Genetic analysis of rabbits identified key genes for traits like coat color, body size, and fertility.

CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.