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This study found that mitochondrial dysfunction in T cells led to defective hair follicle stem cell function and premature skin aging signs in a mouse model.

Some people have a genetic variation that makes them less effective at breaking down drugs.

In this study, α-MSH and cyclic AMP were found to stimulate melanogenesis in hair follicle cultures, while cyclic GMP and melatonin inhibited melanin production but not tyrosinase activity.

This study demonstrated that Forsythiaside A protected against oxidative stress in both cell models and a mouse model of liver damage, suggesting its potential as a liver-protective agent.

This study found that a 50% ethanol extract from marine green alga Chlamydomonas sp. W80 exhibited several bioactive properties, including skin lightening and hair growth promotion effects, with potential implications for bioenergy and high-value coproducts.

This study found that inhibiting mTORC2 in glioblastoma cells reduced DNA repair and increased apoptosis, highlighting its potential role in cancer cell survival and DNA damage response.

This study reviews the current research on the metabolomic profile and antimicrobial properties of the Cannabis plant, highlighting its effective antibacterial activity against multidrug-resistant bacteria while noting a lack of studies on its impact on plant and aquatic pathogens, emphasizing potential agricultural benefits.

This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.

In this in-vitro study, neem leaf extract, combined with oils from Eucalyptus citriodora and Cymbopogon martini, inhibited dermatophyte growth responsible for tinea capitis, showing potential for developing a treatment formulation against the infection.

This study reports the development of a novel protocol to purify human TRPV3 ion channels, revealing functional properties and differences in ligand interactions, enabling further structural and functional research.

This study found that glycolysis in Paneth cells provides lactate to support mitochondrial oxidative phosphorylation in intestinal stem cells, aiding their function and differentiation.

This review discusses the historical and current use of ribosome-inactivating protein-expressing plants in traditional medicine across various cultures and regions, highlighting their role despite a lack of scientific validation.

In this study, the authors identified and characterized the Get3d protein, conserved across plants and photosynthetic bacteria, which localizes to the chloroplast in Arabidopsis thaliana and potentially plays a role in tail-anchored protein targeting, linked to photosynthesis homeostasis.

This study found that the green alga Botryococcus terribilis and its novel compounds significantly promoted hair growth marker gene expression in hair follicle dermal papilla cells without cytotoxic effects.

Different lab conditions and light treatment methods change how human skin cells respond to light therapy.

This project reports that Vitex rotundifolia may have cancer chemotherapeutic potential due to its ability to inhibit MAP kinase phosphorylation, suggesting further investigation into its active constituents.

This study found that the combination of TTNPB and CHIR99021 enhanced the derivation of highly advanced neural stem cells from human pluripotent stem cells, with improved chromatin accessibility and neuroectodermal gene expression, and these cells successfully engrafted in rat hippocampi to ameliorate depression-like symptoms.

This study demonstrated that a metric based on rotational echo intensity in 2H magic-angle spinning NMR can derive kinetic information for conformational exchange without complex modelling, achieving activation barriers consistent with prior findings.

This study found that inhibiting mTORC1 activity with rapamycin significantly increased melanin production and extended hair growth phase in human hair follicles, suggesting potential for managing hair growth and pigmentation disorders.

This study investigated the endophytic bacterial community of Eclipta prostrata, finding that these microorganisms contribute to the plant’s stress tolerance and detoxification, which may enhance its medicinal properties by supporting the synthesis and stability of beneficial metabolites.

This study found that certain pyrazole derivatives may serve as effective 5α-reductase inhibitors with potential use in the treatment of androgenetic alopecia, based on molecular docking analyses.

This study found that murine skin is a target for melatonin bioregulation, as melatonin affected DNA synthesis and tyrosinase activity in skin organ culture.

This study found that systemic administration of NDP-MSH, a melanocortin receptor agonist, provided neuroprotective effects on dopaminergic nigrostriatal neurons in a mouse model of Parkinson's disease, reducing neuroinflammation and suggesting a role for regulatory T cells in these neuroprotective effects.

This review discusses the similarities between myotonic dystrophy and aging, highlighting the role of cellular senescence in its pathophysiology, and reports no new clinical findings; the authors note potential anti-aging therapy applications.

This study found that extracellular ATP released from UVB-irradiated keratinocytes promotes melanin production through the P2X7 receptor, indicating a role for ATP-P2X7 signaling in UV-induced melanogenesis.

In this review, researchers evaluated 111 studies on the biological activities and phytochemical components of the plant Tridax procumbens, emphasizing its ethnobotanical potential and the need for more research to understand its therapeutic benefits, especially in its native tropical regions.

This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.

In this study, researchers discovered that several compounds, including brequinar and 6-azauridine, exhibit significant anti-Zika virus activity using a high-throughput screen assay.

This study found that olorofim demonstrated potent in vitro and in vivo antifungal activity against dermatophytes, resolving skin lesions in a guinea pig model similar to clotrimazole, suggesting it may be a promising treatment for dermatophytosis.