30 citations
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April 1990 in “Clinical Pharmacology & Therapeutics” This study found that coadministering minoxidil with tretinoin cream increased minoxidil absorption nearly threefold in healthy males, attributed to increased stratum corneum permeability.
8 citations
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April 2019 in “Dermatologic Therapy” This study found that applying topical tretinoin can influence follicular sulfotransferase expression, enabling 43% of predicted nonresponders to minoxidil to respond positively in the context of androgenetic alopecia.
3 citations
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January 1990 in “DICP” Minoxidil and tretinoin together may help hair growth but need more research.
3 citations
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February 2016 in “Dermatologic Therapy” Using minoxidil and tretinoin on the skin, along with oral vitamin D, improved hair thickness and density in two girls with woolly hair.
June 2026 in “Skin Appendage Disorders” This source reviews the use of topical tretinoin with minoxidil for androgenetic alopecia, indicating that while combined use may convert some minoxidil nonresponders to responders, clinical evidence is limited and increased absorption may lead to irritation concerns.
June 2025 in “International Journal of Research in Dermatology” In this case series, researchers observed that combining 0.1% tretinoin gel with 5% minoxidil over 90 days improved hair growth and patient satisfaction in androgenetic alopecia patients who did not previously respond to minoxidil alone, with significant increases in hair count, density, and quality.
September 2010 in “Reactions weekly” The combination of tretinoin, minoxidil, and betamethasone valerate may cause severe scalp inflammation.
43 citations
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January 2007 in “American Journal of Clinical Dermatology” This study concluded that a combined once-daily solution of 5% minoxidil and 0.01% tretinoin is as effective and safe as the conventional twice-daily 5% minoxidil application for treating androgenetic alopecia in men.
41 citations
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January 2007 in “Journal of Korean Medical Science” This study found that combining minoxidil with all-trans retinoic acid additively promoted hair growth in vitro by activating certain cell survival pathways and reducing apoptosis markers more effectively than minoxidil alone.
20 citations
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January 2009 in “International Journal of Dermatology” This case report describes a patient with Clouston's syndrome and alopecia who responded positively to topical treatment with minoxidil and tretinoin.
15 citations
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November 2019 in “Cutaneous and Ocular Toxicology” This study investigated a liposomal hydrogel system for delivering minoxidil and tretinoin to treat androgenic alopecia, finding that the system enhanced skin permeation of minoxidil while retaining tretinoin on the skin and was non-irritating in animal tests, suggesting its potential effectiveness.
12 citations
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March 2014 in “ISRN Pharmacology (Print)” This study demonstrated that Ketoconazole, Minoxidil, and Minoxidil with Tretinoin all significantly stimulated hair growth in mice, with Minoxidil alone showing the most effectiveness.
4 citations
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December 2015 in “MVP journal of medical science” In this study, topical minoxidil 5% was found to be just as effective as a combination treatment with minoxidil, azelaic acid, and tretinoin for treating androgenetic alopecia.
1 citations
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July 2017 in “Global journal of pharmacy & pharmaceutical sciences” The study explored niosome formulations containing minoxidil and tretinoin and found increased drug stability and controlled release, suggesting potential as an effective drug delivery system for treating hair loss.
1 citations
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September 2015 in “MVP journal of medical science” In this study, the combination of minoxidil, azelaic acid, and tretinoin showed no significant advantage over minoxidil alone for treating androgenetic alopecia.
June 2026 in “Clinical Case Reports” This case report observed a 5.5-year-old girl with Ectodermal Dysplasia-Syndactyly Syndrome 1, who experienced improved hair density and thickness with topical minoxidil and tretinoin, suggesting a potential adjunctive role for topical retinoids, though confirmation in larger studies is needed.
January 2025 in “International journal of research and scientific innovation” This critique of a 2019 study highlights the potential of a liposomal hydrogel for delivering Minoxidil and Tretinoin to treat androgenetic alopecia, but underscores the need for in vivo trials and further stability and interaction analysis to validate its promise.
This report describes a case where a young woman developed Kerion Celsi, a fungal skin infection, potentially linked to the use of a tretinoin, minoxidil, and betamethasone valerate lotion.
October 2007 in “Inpharma Weekly” 73 citations
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October 1986 in “Journal of the American Academy of Dermatology” This study found that a combination of topical tretinoin and 0.5% minoxidil resulted in terminal hair regrowth in 66% of subjects with androgenetic alopecia over one year.
January 2024 in “SAGE Open Medical Case Reports” This report describes the case of identical twin males, where one applied topical 5% minoxidil for over a year on the beard and mustache area and the other did not, highlighting the anecdotal use of minoxidil for facial hair enhancement.
December 2023 in “Farmateka” Minoxidil is an effective and safe treatment for common hair loss when applied to the skin, but more research is needed for optimal use.
33 citations
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April 1990 in “Dermatologic Clinics” Minoxidil effectively treats hair loss, with better results in women.
23 citations
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December 1995 in “Archives of Dermatology” This case report discusses a 32-year-old man's treatment for advanced androgenetic alopecia using a combination of topical minoxidil and oral finasteride, but no clinical outcomes are detailed.
1 citations
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December 1995 in “Archives of Dermatology” This case report describes a patient with advanced androgenetic alopecia who underwent a 6-month trial of topical minoxidil and oral finasteride, aiming to optimize hair regrowth without surgery.
This study concluded that 5% minoxidil foam or solution applied twice daily is effective and safe for treating male androgenetic alopecia.
January 1989 in “Handbook of experimental pharmacology” This review discusses the impact of drugs on human hair growth, highlighting its psychological importance and noting that most contributions are from clinical perspectives, with some input from biochemists and physiologists.
30 citations
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November 1996 in “Archives of Dermatology” This report describes cases of increased hair loss and scalp sunburns in patients using 3% minoxidil and 0.01% tretinoin, suggesting caution with tretinoin use on sunny days.
19 citations
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March 2011 in “Cutaneous and Ocular Toxicology” Some chemicals absorbed through the skin can cause serious health problems.
10 citations
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May 2015 in “International Journal of Women's Dermatology” This review discusses the unique dermatologic needs and conditions affecting women of color, noting specific skin and hair conditions but reports no clinical results.