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Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Early diagnosis and treatment of TPP can prevent complications.

New guidelines stress early diagnosis and lifestyle changes to manage metabolic syndrome and prevent complications.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

Post-finasteride syndrome's existence is uncertain; more research needed.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Skin doctors should know about skin and kidney disease links to prevent serious kidney problems.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

Cats lose fur due to various reasons, including allergies, infections, genetics, hormones, diet, cancer, stress, and some conditions are treatable while others are not.

Testosterone raises blood pressure and changes kidney protein levels.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.