116 citations
,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
101 citations
,
July 2020 in “Dermatologic therapy” This systematic review reports that "COVID toes" and other skin manifestations can be initial signs of COVID-19, and advises immunosuppressive therapy adjustments only for infected or at-risk patients.
84 citations
,
April 2005 in “Dermatologic Clinics” Treatments for melanin disorders exist, but more effective options needed.
77 citations
,
January 1980 in “Carcinogenesis” This study found that TPA was significantly more effective than mezerein in inducing dark basal keratinocytes in mouse skin, which may be important in early tumor promotion stages.
73 citations
,
March 2017 in “Scientific Reports” This study demonstrates that bioengineered tooth germ autologously transplanted in a postnatal canine model can achieve functional tooth restoration, suggesting its potential for future clinical regenerative medicine.
73 citations
,
July 2016 in “Cosmetics” This review discusses the use of mushrooms and their bioactive compounds in cosmeceuticals and nutricosmetics and reports no new clinical findings, highlighting potential areas for future research and development.
69 citations
,
June 2017 in “Experimental Biology and Medicine” This review discusses the advancements and challenges in developing in vitro human skin models incorporating components like vasculature for drug testing and disease research, but reports no new clinical results.
69 citations
,
January 2013 in “Frontiers in Immunology” This review summarizes existing knowledge on the role of FOXN1 as a key regulator of thymic epithelial cell lineage and function, reporting no new experimental results.
66 citations
,
May 2012 in “Scientific Reports” This study demonstrated that bioengineered hair follicles reconstituted from embryonic skin cells and transplanted into hosts can restore physiological hair functions, suggesting potential applications for treating alopecia.
64 citations
,
March 2005 in “Journal of Investigative Dermatology” This study found that brain-derived neurotrophic factor (BDNF) inhibited hair shaft elongation and induced premature catagen development in cultured human hair follicles, partially through transforming growth factor β2.
60 citations
,
January 1989 in “Toxicologic Pathology” This paper discusses the pathogenesis of cardiovascular lesions in dogs associated with minoxidil, noting that lesions were not prevented by adrenergic blockade or neural activity suppression, and highlights the differences in injury progression between coronary arteries and the right atrium.
59 citations
,
September 2008 in “Experimental dermatology” This study reports that C3H/HeJ mice and DEBR rats serve as effective models for screening potential treatments for human alopecia areata, despite certain challenges in predictability and cost.
50 citations
,
November 2010 in “Plastic and Reconstructive Surgery” This study suggests that Botox injections may increase hair count and reduce hair loss in men with androgenetic alopecia, potentially through increased blood flow and oxygen to the scalp.
49 citations
,
October 2014 in “International Scholarly Research Notices” This review explores the medicinal properties of Eclipta alba and its phytoconstituents and reports their potential for developing new drugs, but presents no new research results.
43 citations
,
February 2020 in “Clinica chimica acta” This review discusses the role of phytochemical nanoparticles in cervical cancer therapy and reports no new clinical results; the authors highlight their potential advantages over conventional chemotherapy.
40 citations
,
March 2019 in “Nature Communications” This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.
40 citations
,
November 2016 in “Molecules” This review discusses the historical and current use of ribosome-inactivating protein-expressing plants in traditional medicine across various cultures and regions, highlighting their role despite a lack of scientific validation.
40 citations
,
January 2016 in “Elsevier eBooks” This article explains the structure and multifunctional roles of the human skin, including its protective, regulatory, and sensory functions, but does not report new research findings.
39 citations
,
June 2019 in “Toxins” This review explores the therapeutic potential of bee venom for treating various skin diseases, discussing its mechanisms and effects but reports no new clinical findings.
38 citations
,
July 2010 in “Clinical, cosmetic and investigational dermatology” This review discusses systemic antifungal treatments for tinea capitis in children, noting that newer agents like terbinafine and itraconazole require shorter courses than the traditional griseofulvin, but may be more costly.
36 citations
,
March 2014 in “Biomaterials” This study found that the 11R-No. 10 peptide, delivered transdermally, significantly inhibited melanogenesis and produced a whitening effect in a UV-induced sun-tanning guinea pig model without cytotoxicity.
34 citations
,
August 2002 in “British Journal of Dermatology” This study observed that two patients treated with interferon α-2b and ribavirin for chronic hepatitis C experienced complete and reversible straightening of their natural curly hair, which recurred with treatment resumption.
32 citations
,
December 2014 in “Journal of experimental botany” In this study, the authors concluded that arabinogalactan proteins recognized by specific antibodies are involved in the differentiation and development of barley root epidermal cells, contributing to root hair development.
32 citations
,
January 2008 in “Journal of Microencapsulation” In this study, nanocapsule-based preparations containing hinokitiol promoted hair growth in mice comparably to Minoxidil solution, as indicated by photographic and histological analysis.
31 citations
,
January 2017 in “Phytotherapy Research” This review reports on the traditional and ethnopharmacological uses of Ziziphus jujuba Mills, noting its increasing global popularity for treating various ailments, but highlights that its acceptance into the European Pharmacopoeia remains unresolved due to scientific and regulatory challenges.
30 citations
,
April 2018 in “Experimental Dermatology” This review discusses the historical development and current challenges in in vitro hair follicle culture, highlighting a need for advanced models using cell lines and tissue engineering, and reports no new results.
30 citations
,
February 2018 in “Journal of Pharmacy and Pharmacology” This review discusses the traditional uses and pharmacological properties of Hedychium spicatum, noting that while some traditional uses are supported by scientific studies, further research on its applications is needed.
30 citations
,
March 2016 in “European Journal of Pharmaceutical Sciences” This study found that using drug microplates in transdermal finasteride films enhances aqueous solubility and skin permeation compared to films with pure finasteride.
28 citations
,
October 2013 in “Cornea” This review discusses the strategies and progress in developing bioengineered organ replacement therapies but reports no new clinical results, highlighting the potential for future regenerative solutions.
28 citations
,
September 2013 in “Expert Opinion on Therapeutic Patents” This review discusses various resveratrol derivative patents for therapeutic, nutraceutical, and cosmetic use, but reports no clinical results and notes that claims of improved efficacy lack trial evidence.