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In this study, Epimedii Folium extract was found to enhance melanin production and promote pigmentation through mechanisms involving the MAPK/ERK1/2 pathway in both in vitro and in vivo models.

This review examines the histochemistry and keratinization processes of human hair, exploring the structural roles of keratin proteins, protein chains, and lipids, but offers no new results.

This article presents a biochemical model to explain how drug molecules are incorporated into hair, highlighting factors such as drug melanin affinity and the role of physico-chemical properties.

The researchers concluded that baicalin may promote hair growth and follicle proliferation by activating the AKT pathway, suggesting its potential as a treatment for alopecia.

This study found that sodium valproate nanospanlastics could be an effective and safer method for treating androgenic alopecia, with results comparable to minoxidil but fewer side effects.

This study found that non-pigmented hair follicles have significantly lower expression of nucleotide excision repair genes, which may be associated with reduced melanin production capacity in these follicles.

This review discusses the mechanisms and potential benefits of platelet-rich plasma therapy for various skin conditions and reports no new clinical findings.

This study found that a 50% ethanol extract from marine green alga Chlamydomonas sp. W80 exhibited several bioactive properties, including skin lightening and hair growth promotion effects, with potential implications for bioenergy and high-value coproducts.

Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.

This review discusses various aspects of hair color, including its formation and evolutionary variations, based on research presented at the 4th Intercontinental Meeting of Hair Research Societies 2004, without providing new experimental results.

This study found that Heated radish extract potently suppressed melanin production in vitro and reduced wrinkle formation and collagen degradation in vivo, suggesting its potential as a skin whitening and antiaging product.

This review discusses how hair follicle light sensitivity is linked to mesenchymal remodeling and suggests that this connection influences photoepilation outcomes and optimal treatment strategies, reporting no new clinical results.

This study used transcriptome analysis to explore the genetic mechanisms behind the development and seasonal variation of nuptial pads in R. chensinensis, identifying key genes and processes that suggest the pads' development involves complex regulatory pathways, particularly those related to cell cycle and hormone synthesis.

This article discusses how drug molecules integrate into hair fibers, focusing on biological transport mechanisms and physicochemical factors, but reports no new experimental findings.

This article reviews the impact of H2O2-redox homeostasis on hair follicle pigmentation via tyrosinase and associated mechanisms, discussing primarily findings from murine models without providing new clinical results for humans.

This study observed that long-term UV-A exposure and semi-permanent dye treatment can cause significant structural damage to human hair, particularly affecting the cuticle and cortex layers.

This study found that low fluence photoepilation with intense pulsed light targets the pigmented area of hair follicles, causing temporary hair loss by inducing a catagen-like state without severe follicle damage.

This article discusses the interactions between keratinocytes and melanocytes in maintaining epidermal and hair follicle homeostasis, without reporting new experimental results.

This study found that sunlight exposure causes significant structural and chemical damage to hair, including cuticle loss, cortex damage, and discoloration, with water playing a major role in discoloration of brown hair.

This study found that differentially expressed genes in horses with white versus black coats may regulate coat color, providing insights into the genetics of skin melanin synthesis.

This study found that Angiotensin II is expressed more in black sheep skins compared to white sheep skins, suggesting its involvement in coat color regulation.

This paper introduces a new understanding that the human hair follicle medulla lacks metabolic activity for H2O2 breakdown, indicating that H2O2 decomposition occurs primarily in the cortical areas.

In this laboratory study, α-mangostin was found to significantly reduce melanin content and downregulate pigmentation-related genes in cultured skin and B16F10 cells, suggesting potential application as a natural whitening agent in sunscreen development.

This study provides ex vivo proof-of-principle that low-intensity ultrasound may protect human hair follicles from paclitaxel-induced damage, potentially reducing chemotherapy-related alopecia.

This review discusses recent in vitro and in vivo research suggesting that components of ginseng, such as ginsenosides and gintonin, may have potential skincare benefits, including anti-aging effects and treatment of skin conditions like atopic dermatitis and hypertrophic scars.

This study found that administering mesenchymal stem cells to UV-exposed mice reduced melanin levels, although the decrease was not statistically significant.

This abstract describes the role of melanin in determining hair color and protecting against UV radiation, highlighting how its production affects hair health, growth, and vitality, with reduced production contributing to greying with age.

This study examined developing hair cortex with electron microscopy and found that keratin fibrils form between specific regions in hair follicles and aggregate into twisted cables.

Treatments for melanin disorders exist, but more effective options needed.

This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.