November 2011 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS” This study found that Polyomavirus A2 infection in mice led to the development of pilomatricomas in hair follicles, with the virus replicating initially in the skin and later infecting matrix cells.
June 2008 in “Experimental Dermatology” This study suggests that combining 17-beta estradiol with prednisolone could accelerate hair regrowth after chemotherapy-induced alopecia in humans, based on preclinical findings using an in vitro model.
January 2007 in “Sen'i Gakkaishi” This study found that Mf-rich-fiber in human hair underwent significantly greater degradation by proteases than Ma-rich-fiber, especially when treated with Proteinase K.
Hair coloring and bleaching can permanently break down hair protein and temporarily change its properties.
This study found that, compared to oxidative treatments, reductive perm-waving more severely impacts the intermediate filaments in European human hair, while both treatments alter denaturation kinetics in a first-order manner.
August 2005 in “The Journal of Cell Biology” This abstract provides a graphic illustrating that mice lacking the Sgk3 gene exhibit thin coats and abnormal hair, suggesting a role for Sgk3 kinase in hair follicle growth, but reports no new experimental findings.
January 2002 in “Basic medical sciences and clinics” This review explores hypotheses about hair follicle stem cell function in morphogenesis and cycling, highlights the importance of dermal papilla cells and signaling pathways, and provides no new clinical findings.
This narrative review discusses the hormonal control of hair growth, particularly focusing on dihydrotestosterone and its role in the pilosebaceous unit and androgen-related hair conditions, and does not report new findings.
March 2026 in “Mendeley Data” This study found that human dermal papilla cells are embedded in a basement membrane-like extracellular matrix, which is essential for their aggregation and function, as supported by evidence that Matrigel enhances dermal papilla cohesion and gene expression compared to collagen I, which promotes cell dispersion.
February 2026 in “ACS Biomaterials Science & Engineering” In this study, researchers successfully generated hair follicle organoids using human induced pluripotent stem cells (hiPSCs) with collagen I as a microenvironment, demonstrating potential applications in hair regeneration, though fully human organoids require additional approaches.
March 2023 in “Research Square (Research Square)” In this study, researchers found that changes in immune cell infiltration and immune-related gene expression may contribute to the immune microenvironment changes in male androgenetic alopecia.
September 2022 in “Journal of Theoretical Biology” This study developed a mathematical model to explore hair follicle regeneration mechanisms, showing that low spontaneous apoptosis rates help regenerate hair follicles after ionizing radiation, while high rates lead to degeneration during the catagen phase.
December 2022 in “Nature Communications” This study found that a new "bead-jet" printing system for mesenchymal stem cells in Matrigel beads improved skeletal muscle regeneration and skin healing in a high-density, sparse pattern.
30 citations
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May 1980 in “Journal of the American Academy of Dermatology” In this study, three patients with alopecia areata exhibited spotty absence of the whiteness of their nail lunulae, potentially due to defects in the matrical epithelium.
20 citations
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November 2004 in “Archives of Pathology & Laboratory Medicine” This case report describes a rare instance of melanocytic matricoma, a benign pigmented papule found in sun-damaged skin of an elderly individual, highlighting its distinct clinical and pathological features.
1 citations
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September 2022 in “Biomaterials advances” This study used 3D bioprinting to implant epidermal stem cells, skin-derived precursors, and Matrigel into mouse wounds, successfully regenerating hair follicles and skin components within four weeks, with minimal impact on stem cell viability and stemness.
1 citations
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January 2017 The document outlines criteria to identify and differentiate neoplasms based on follicular characteristics.
1 citations
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January 2012 in “Journal of Toxicologic Pathology” This case report describes a hybrid cyst in a Sprague-Dawley rat, showing both infundibular and matrical differentiation similar to different parts of normal hair follicles.
1 citations
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January 2004 in “Adelaide Research & Scholarship (AR&S) (University of Adelaide)” This study concludes that SPARC is likely a secondary response during the hair cycle's transitional phases, indicating tissue-remodeling processes similar to those in wound repair, rather than initiating these transitions.
July 2023 in “Eurasian journal of science and engineering” In this study, researchers reviewed various traditional herbal remedies, such as Tribulus terrestris and Matricaria chamomilla, focusing on their global medicinal use and discussing some of the chemical components that contribute to their biological activity.
January 2022 in “Acta botanica Caucasica” This study evaluated herbal cosmetic products used in Turkiye, identifying 140 plant species and highlighting walnut, common nettle, and grape as popular for various traditional uses.
This study found that in the San Plácido parish of Ecuador, various medicinal plants were widely used by locals for treating common ailments, with the most utilized species being Matricaria chamomilla L. and Mentha rotundifolia L.
January 2018 in “Turkiye Klinikleri Journal of Dermatology” This study identified the most common plants in hair cosmetics, like shampoos and dyes, with Rosmarinus officinalis L. and Lawsonia inermis L. leading, to serve as a reference for future research and healthcare professionals.
1235 citations
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December 2013 in “Nature” This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.
990 citations
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October 1999 in “Development” This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.
480 citations
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August 2014 in “Nature Biotechnology” This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.
466 citations
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August 2004 in “Journal of the American Academy of Dermatology” This article reviews the current literature on rosacea, focusing on the new subtype classification system and the main theories of its pathogenesis, but reports no new clinical results.
363 citations
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March 2017 in “Nature Communications” This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.
341 citations
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November 2009 in “The FASEB Journal” This article reviews the multifunctional roles of calreticulin outside the ER and highlights its impact on wound healing in animal models, but reports no new clinical results.
305 citations
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December 2000 in “The EMBO Journal” Inhibiting Bmp signaling disrupts hair growth and differentiation.