Changes in Hair: Causative Factors

    January 1996
    Masumi Inaba, Yoshikata Inaba
    TLDR DHT, not testosterone, mainly affects hair growth and related conditions.
    The document discussed the hormonal control of hair growth, focusing on the role of dihydrotestosterone (DHT) as the active form of testosterone in hair follicles. It highlighted that glucose-6-phosphate-dehydrogenase (G6PDH) activity, stimulated by cyclic adenosine monophosphate (AMP), increased significantly during the anagen phase of hair growth. The study noted a correlation between alopecia progression and declining androgen levels, emphasizing that 5α-DHT, rather than testosterone, stimulated matrix cells in hair follicles, particularly in women with hirsutism. This mechanism was also relevant to sebaceous gland activity in acne.
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      community Blood work, is it worth to pay for it?

      in Treatment  6 upvotes 5 months ago
      The user is considering getting blood work to investigate the cause of ongoing hair loss despite using finasteride and dutasteride. Others suggest that while blood tests can provide useful health information, they may not change the hair treatment outcome.

      community What are your thoughts on pre-finasteride blood work?

      in Finasteride/Dutasteride  1 upvotes 2 years ago
      The user is considering resuming finasteride after a 6-month break and is debating the necessity of extensive blood work, including hormone and health markers, to establish a baseline. They are unsure if the tests are necessary since they experienced no side effects previously.

      community Saying creatine causes loss on fin/dut makes no sense and this is why

      in Finasteride/Dutasteride  42 upvotes 2 years ago
      The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.

      community Does whey protein and creatine aggravate hair loss?

      in Research/Science  82 upvotes 2 years ago
      The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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