November 2025 in “Communications Biology” The researchers reported creating a Human Hair Atlas that maps over 1200 molecular species in hair, revealing up to 50% variation in metabolite and lipid levels along the hair's length, and identified 122 exposome-related compounds from personal care products.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.
10 citations
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August 2023 in “Developmental cell” In this study, researchers used advanced techniques to map the early embryonic development of mouse skin, identifying diverse cell populations and uncovering complex interactions essential for skin structure, signaling, and function.
2 citations
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February 2025 in “Journal of Investigative Dermatology” In this study, researchers used quantitative fate mapping to investigate how the infundibulum, part of the epidermis, is maintained during adulthood, finding that progenitors maintain this tissue through stochastic cell fate choices, with cells at the bottom providing transient support during hair growth phases.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers created a comprehensive transcriptome map of human hair follicle compartments, identifying compartment-specific genes and providing a resource for potential therapeutic interventions.
March 2026 in “Cell Transplantation” In this study, a bibliometric and science-mapping analysis revealed that cardiac xenotransplantation research is expanding rapidly, with significant collaboration primarily among institutions in the United States, Europe, and East Asia, and a focus on gene-edited donors and clinical trial readiness.
January 2016 in “Memorial University Research Repository (Memorial University)” This study suggests that hereditary hyperplastic gingivitis in silver foxes may involve the MAPK signaling pathway, with potential androgen effects influencing disease severity.
16 citations
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February 2019 in “Pediatric Blood & Cancer” In this study, 96% of children with CNS tumors receiving MAPK and mTOR inhibitors experienced common, treatable skin reactions, occasionally requiring therapy adjustments.
16 citations
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December 2001 in “Dermatologic Therapy” This review summarizes current genetic knowledge of alopecia areata and provides a theoretical framework for future genetic mapping studies, but reports no new results.
5 citations
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October 2018 in “Journal of Mind and Medical Sciences” In this literature review, researchers reported that sentinel lymph node mapping appears safe and effective for early stage ovarian cancer patients, potentially reducing unnecessary lymph node dissections, though it is not yet standard practice, necessitating further studies.
1 citations
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April 2025 in “Frontiers in Medicine” This editorial synthesizes research on UV-induced skin damage, highlighting potential therapeutic strategies by mapping cellular changes, identifying molecular mechanisms, demonstrating melanocyte protection, and proving combination therapy effectiveness in conditions like vitiligo.
1 citations
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July 2024 in “International Journal of Cosmetic Science” In this study, researchers used advanced infrared microspectroscopy techniques to map the chemical composition of human hair, revealing new insights such as the presence of glycogen in the outer root sheath and the widespread distribution of calcium carboxylates in the hair cuticle.
1 citations
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February 2023 in “JMIR. Journal of medical internet research/Journal of medical internet research” This study used social media data to identify more and milder COVID-19 symptoms than clinical research and to map symptom evolution over 27 months, highlighting differences between the Delta and Omicron periods.
June 2026 in “Frontiers in Cell and Developmental Biology” In this study, researchers used single-cell RNA sequencing to map the hair follicle microenvironment in fine-wool sheep, identifying specific cell types and gene expressions that influence wool fiber diameter, with dermal papilla cells playing a significant role in hair follicle development.
October 2024 in “Acta Biomaterialia” This study introduced a novel method that uses upright structured illumination microscopy and atomic force microscopy to map the mechanical properties of thick living tissue slices, revealing the intricate mechanical heterogeneity of mouse skin and effects of preservation techniques on tissue stiffness.
January 2005 in “ScholarSpace (University of Hawaii at Manoa)” This project reports that Vitex rotundifolia may have cancer chemotherapeutic potential due to its ability to inhibit MAP kinase phosphorylation, suggesting further investigation into its active constituents.
22 citations
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February 2008 in “Journal of Neurochemistry” This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.
7 citations
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April 2000 in “Mammalian Genome” This study identified a new mutation in SELH/Bc mice causing distinctive whisker and body hair abnormalities, mapped near the type I keratin cluster on chromosome 11.
5 citations
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July 2017 in “Molecular Medicine Reports” This study observed that ethanol extracts of Lygodium japonicum spores significantly reduced inflammatory responses in LPS-stimulated murine macrophages in vitro by negatively regulating p38 MAPK and NF-κB.
4 citations
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March 2018 in “Animal biotechnology” This study suggests that the LAMTOR3 gene may play a role in the development of hair follicles and cashmere growth in Liaoning cashmere goats by influencing the MAPK signaling pathway.
3 citations
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September 2024 This study developed 3DEEP, a tissue clearing and spatial transcriptomic method, to map hair follicle development in a single time point from a 12-hour-old mouse, detailing molecular stages, signaling dynamics, and structural changes within developing follicles.
November 2025 in “Scholarly Commons (Embry–Riddle Aeronautical University)” This review discusses how urban air pollutants may influence the regulation of JAK3 signaling in alopecia areata and reports no new experimental results; the authors integrate existing data to map potential pathways and biomarkers.
December 2023 in “Animals” This study used single-cell RNA sequencing to analyze 26,573 cells from the scapular skin of yaks, identifying 11 major cell types and providing insights into the diversity and morphogenesis of hair follicle cell types through detailed maps of DP cells and dermal fibroblasts.
This study demonstrates that the trichohyalin gene is located at chromosomal region 1q21, where several other genes related to epidermal differentiation also map.
This study on Antirrhinum trichomes found that stickiness in A. hispanicum is due to a recessive allele and mapped it to a specific region on Chromosome 1, while baldness in A. siculum likely involves a novel hairy allele.
The researchers developed a comprehensive human skin cell atlas using data from various studies and established a consensus nomenclature for normal human skin in this project, which also includes a deep learning-based method for more effective reference mapping of new cells.
November 2006 in “評価・診断に関するシンポジウム講演論文集” This study found that KSR1 is essential for v-Ha-ras-mediated skin tumor formation in mice but not for MT-driven mammary tumor genesis, suggesting its potential as a therapeutic target in Ras/MAPK signaling.
This research by Yuan et al. focused on developing a comprehensive human skin cell atlas, analyzing various cell types and diseases, and introduced a deep learning method, scSEA, for unbiased reference mapping, potentially discovering new cell types.
202 citations
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July 2022 in “Biomedicine & Pharmacotherapy” This review compiles and discusses the ethnomedicinal uses, pharmacological activities, and phytochemistry of pomegranate, suggesting potential future applications in drug discovery for various ailments but reports no new clinical results.
July 2026 in “Journal of Investigative Dermatology” GLP-1 therapies can cause hair loss, but hair often regrows after stopping or reducing the drug.