68 citations
,
May 2018 in “PLOS Biology” This study demonstrates that inhibiting SFRP1 with the antagonist WAY-316606 enhances hair growth in human scalp hair follicles ex vivo by facilitating Wnt signalling.
68 citations
,
December 2014 in “Cell Biochemistry and Function” This review examines the role of nuclear hormone receptors in skin wound repair processes and reports no new clinical results, highlighting the importance of their interaction with skin cells for effective healing.
68 citations
,
June 2005 in “Expert Opinion on Therapeutic Targets” This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.
68 citations
,
April 2002 in “Journal of Alternative and Complementary Medicine” This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.
67 citations
,
May 2018 in “Journal of Ginseng Research” This paper highlights the need for a comprehensive red ginseng monograph to provide standardized information on its components, certified functionality, efficacy, action mechanisms, and safety, especially given its widespread use as a health functional food in South Korea and interest in its benefits worldwide.
66 citations
,
May 2021 in “Science Advances” In this study, researchers found that electrospun membranes with aligned surface topography advanced the immune response towards an adaptive stage and highlighted the role of T cells in hair follicle regeneration in mice, showcasing the intricate interactions between immune and skin cells.
65 citations
,
April 2021 in “Natural Products and Bioprospecting” This review discusses the traditional uses and pharmacologically active compounds of 22 Dendrobium species for dermatological disorders but reports no new results, highlighting the need for further research.
65 citations
,
June 2020 in “Stem Cell Research & Therapy” This review discusses recent advances in how proinflammatory cytokines affect epidermal stem cell function during skin wound healing and introduces potential therapies targeting these cells and cytokines.
65 citations
,
May 2017 in “Advances in wound care” This review discusses the role of Toll-like receptors in wound healing and highlights their potential therapeutic value but notes that their role in human wound healing and chronic wounds is not well understood.
65 citations
,
February 2017 in “Pflügers Archiv - European Journal of Physiology” This review examines the roles of macrophages and Langerhans cells in skin homeostasis and suggests that understanding these functions can aid in developing therapies for skin and hair regeneration, but it reports no new research findings.
65 citations
,
March 2016 in “Lasers in Medical Science” This review found that many low-level light therapy studies report beneficial effects but often fail to provide adequate measurement details, affecting the reliability and repeatability of the research.
65 citations
,
January 2011 in “Frontiers in Endocrinology” This review summarizes the role of neurosteroids in seizure disorders and highlights the potential of neurosteroid replacement therapy in epilepsy but presents no new clinical findings.
65 citations
,
April 2002 in “Journal of Alternative and Complementary Medicine” This study found that 60% of men with mild to moderate androgenetic alopecia showed improvement after treatment with botanically derived 5AR inhibitors, suggesting these compounds may be effective, though larger trials are needed.
64 citations
,
June 2014 in “Journal of The American Academy of Dermatology” This study found that a peripilar white gray halo around hair emergence is a highly specific and sensitive dermatoscopic feature for diagnosing central centrifugal cicatricial alopecia in African American patients with mild central thinning.
62 citations
,
October 2017 in “JAMA facial plastic surgery” This study reported that using condensed nanofat combined with fat grafts significantly improved the aesthetic and functional aspects of atrophic facial scars in 20 patients, as assessed by both patients and plastic surgeons using the Patient and Observer Scar Assessment Scale.
62 citations
,
November 2009 in “Aging Cell” Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.
62 citations
,
July 1993 in “Journal of Investigative Dermatology” Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
61 citations
,
May 2015 in “Planta” Certain fungi and bacteria help orchid seeds germinate and plants grow better.
60 citations
,
July 2020 in “ACS Nano” This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.
60 citations
,
May 2015 in “Archives of dermatological research” This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.
60 citations
,
April 2012 in “Physiology” This article explores how extrafollicular environments and stem cell configurations influence hair and feather regeneration but provides no new experimental results.
59 citations
,
July 2015 in “Journal of Immunology” This study found that disrupting inflammasome signaling by eliminating caspase-1 and -11 in mice reduced skin inflammation and delayed the onset of disease, highlighting their role in skin disease pathogenesis.
58 citations
,
January 2003 in “Thrombosis and Haemostasis” This review discusses how androgens may regulate wound healing and inflammation, noting that testosterone appears to inhibit healing and promote inflammation, but it reports no new clinical results.
research ACNE
58 citations
,
January 1997 in “Dermatologic Clinics” This study found that daily consumption of soft drinks significantly increases the risk of moderate-to-severe acne in adolescents, particularly if sugar intake from these drinks exceeds 100 grams per day.
57 citations
,
March 2019 in “Immunity” This review discusses the roles of immune responses and cells in skin health and disease, emphasizing recent insights into their mechanisms and potential therapeutic applications, but presents no new experimental results.
55 citations
,
April 2022 in “Journal of Molecular Medicine” This review discusses the relationship between aging, chronic inflammation, and immunosuppression, suggesting that these interconnected processes may contribute to tumorigenesis and premature aging, but reports no new experimental results.
55 citations
,
April 2018 in “Advanced Healthcare Materials” This review discusses recent advances in scarless wound healing, focusing on strategies to create pro-regenerative scaffolds for repairing damaged skin, and reports no new clinical results.
55 citations
,
April 2010 in “Cancer and Metastasis Reviews” This article discusses the complex role of TGFβ in cancer progression, highlighting its dual function as both a tumor suppressor in early stages and a promoter in later stages, without reporting new results.
52 citations
,
October 2010 in “Antiviral Therapy” This review discusses recent advances in monophosphate prodrug strategies for HCV drug discovery, aiming to enhance oral absorption and stability, and reports no new clinical results.
51 citations
,
November 2005 in “Journal of Medical Primatology” This study observed that hair loss in captive rhesus macaques varies with season, sex, and housing conditions, and is significantly correlated with HPA axis activity as indicated by faecal cortisol metabolites.