August 2016 in “Journal of Investigative Dermatology” The enzyme CD73 helps control human hair growth and could be targeted to treat hair growth disorders.
March 2014 in “CRC Press eBooks” Human head hair can grow very long and is thicker than most body hair.
February 2014 in “Journal of medical sciences” Treating androgenic alopecia can significantly increase hair thickness, especially in males, with hair color and scalp location also affecting hair diameter.
September 2011 in “Archives of dermatology” The child was diagnosed with cutaneous leishmaniasis.
May 1985 in “Journal of The American Academy of Dermatology” The book "Diseases of the Hair and Scalp" has outdated information and confusing content, but may still offer some insights.
May 2022 in “The FASEB Journal” Finasteride may help treat Neutrophil Actin Dysfunction by reducing LSP1 gene activity.
April 2022 in “Microbiology and Immunology” A specific DNA pattern in Malassezia restricta may be linked to hair loss in men.
April 2020 in “The FASEB Journal” Finasteride may cause lasting sexual issues by altering specific genes in human cells.
176 citations,
February 2006 in “Cancer Research” The study demonstrated that the loss of Patched 1 (Ptch1) function in the basal cell population of mouse skin was sufficient to induce rapid skin tumor formation, similar to human basal cell carcinoma (BCC). The research showed that Ptch1 did not affect the nuclear translocation of β-catenin or activate the Notch pathway, but its absence led to the nuclear accumulation of cell cycle regulators cyclin D1 and B1. This suggested that Ptch1 acted as a tumor suppressor by inhibiting cell cycle progression at the G1-S and G2-M phases, functioning as a "gatekeeper." The mouse model used in this study, due to its high frequency and rapid onset of tumors, was considered ideal for testing therapeutic strategies, including Patched pathway inhibitors.
161 citations,
August 2013 in “Journal of experimental botany” Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.
125 citations,
May 2007 in “Journal of The American Academy of Dermatology” The BASP classification is a detailed and accurate way to categorize hair loss in both men and women.
90 citations,
August 2006 in “British Journal of Dermatology” PRIDE syndrome includes skin and hair issues from cancer treatment with EGFR inhibitors.
84 citations,
June 2013 in “Stem Cells Translational Medicine” New methods for skin and nerve regeneration can improve healing and feeling after burns.
50 citations,
December 2000 in “Journal of Pharmaceutical Sciences” Hair follicles significantly enhance electroosmotic transport during iontophoresis.
50 citations,
August 1985 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.
40 citations,
March 2022 in “Small” Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.
33 citations,
July 2007 in “Skin research and technology” Thicker hair is stronger, regardless of age, gender, or other factors.
31 citations,
February 1972 in “Experientia” The diphosphonate was the most effective at preventing calcification in rats.
30 citations,
July 2009 in “Experimental and clinical endocrinology & diabetes” Cyproterone acetate effectively treats sexual disorders by reducing sexual functions and is generally well-tolerated.
29 citations,
February 2007 in “Hormone and metabolic research” Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.
27 citations,
January 2012 in “Current Topics in Microbiology and Immunology” Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.
26 citations,
January 2016 in “Annals of Dermatology” Ecklonia cava polyphenols help increase human hair growth and reduce hair loss.
26 citations,
March 2014 in “International journal of pharmaceutics” Researchers created a skin treatment that could effectively deliver medication into hair follicles.
26 citations,
June 2001 in “PTR. Phytotherapy research/Phytotherapy research” Procyanidin B-2 lotion might help men grow thicker hair without side effects.
25 citations,
March 2017 in “Steroids” Allopregnanolone increases growth and changes gene activity in human brain cancer cells.
22 citations,
August 2015 in “PloS one” Keratin from hair binds well to gold and BMP-2, useful for bone repair.
20 citations,
June 2016 in “Magnesium research” Hair follicles help magnesium get through the skin more effectively.
16 citations,
January 1998 in “Dermatology” Human sebaceous glands can grow normally for a week without certain growth factors, and adding estrogen reduces their oil production without affecting cell growth.
15 citations,
October 2010 in “Archives of Toxicology” A yeast-based test can detect the steroid methyltestosterone in urine longer than traditional methods.
14 citations,
July 2021 in “Biomedicines” Platelet-rich treatments can help improve wound healing and tissue repair.