Finasteride Induces Epigenetic Modulation of LSP1: A Gene Implicated in Neutrophil Actin Dysfunction Disease

May 2022 in “ The FASEB Journal ”

Churchill Ihentuge, Anthonei Csoka

finasteride Lymphocyte Specific Protein 1 LSP1 DNA methylation Neutrophil Actin Dysfunction Leydig cells Propecia

TLDR Finasteride may help treat Neutrophil Actin Dysfunction by reducing LSP1 gene activity.

The study investigated the effects of finasteride on the methylation and expression of the Lymphocyte Specific Protein 1 (LSP1) gene, which is involved in neutrophil motility and implicated in Neutrophil Actin Dysfunction. Human Leydig cells were treated with 0.5 μM finasteride for 14 days, and whole-genome DNA methylation analysis revealed that finasteride induced downregulation of the LSP1 gene through methylation. This suggests that finasteride could potentially be used to treat Neutrophil Actin Dysfunction by modulating the expression of LSP1.

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