Finasteride Induces Epigenetic Modulation of LSP1: A Gene Implicated in Neutrophil Actin Dysfunction Disease

    May 2022 in “ The FASEB Journal
    Churchill Ihentuge, Anthonei Csoka
    TLDR Finasteride may help treat Neutrophil Actin Dysfunction by reducing LSP1 gene activity.
    The study investigated the effects of finasteride on the methylation and expression of the Lymphocyte Specific Protein 1 (LSP1) gene, which is involved in neutrophil motility and implicated in Neutrophil Actin Dysfunction. Human Leydig cells were treated with 0.5 μM finasteride for 14 days, and whole-genome DNA methylation analysis revealed that finasteride induced downregulation of the LSP1 gene through methylation. This suggests that finasteride could potentially be used to treat Neutrophil Actin Dysfunction by modulating the expression of LSP1.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 7 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Lost density 60% all over scalp in 120 days (4months)

      in Update  10 upvotes 10 months ago
      A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

    Similar Research

    5 / 1000+ results