The Effect of Polyphloretin Phosphate, Polyoestradiol Phosphate, a Diphosphonate, and a Polyphosphate on Calcification Induced by Dihydrotachysterol in Skin, Aorta, and Kidney of Rats

    February 1972 in “ Experientia ”
    P. A. Casey, G. Casey, H. Fleisch, R. G. G. Russel
    Studysummary This study found that the diphosphonate ethan-1-hydroxy-1,1-diphosphonat was the most effective compound in preventing calcifications in rats induced by DHT, compared to other phosphatase inhibitors and polyphosphates tested.
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    The study investigated the ability of two phosphatase inhibitors (polyphloretin phosphate and polyoestradiol phosphate), a polyphosphate (hexametaphosphate), and a diphosphonate (ethane-1-hydroxy-1,1-diphosphonate) to prevent calcification in the skin, aorta, and kidneys of rats induced by dihydrotachysterol (DHT). The diphosphonate was found to be the most effective inhibitor, followed by the polyphosphate and the two phosphatase inhibitors. Additionally, the phosphatase inhibitors were tested for their ability to slow down calcium phosphate precipitation in vitro. Polyphloretin phosphate demonstrated this ability at concentrations of 10^-5 M and higher, while polyoestradiol phosphate was ineffective.
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