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research Effectiveness of low-level laser therapy in lichen planopilaris
This study found that low-level laser therapy may reduce inflammation and increase hair thickness in patients with lichen planopilaris after six months of treatment, though the small sample size limits the findings.
research Evaluation of the Thrombolytic and Antioxidant Activity of Leaf Extracts of Plumbago zeylanica L.
This study found that methanolic leaf extract of Plumbago zeylanica L. demonstrates strong thrombolytic and antioxidant activities and shows promise as a source of such agents.
research Anti-vitiligo Mechanisms of Traditional Chinese Medicine Compound Baqia Danshen Liniment: Network Pharmacology, Molecular Docking, and Animal Model Insights
In this study, researchers found that Compound Baqian Danshen Liniment may improve vitiligo in mice by promoting melanocyte activity and reducing inflammation and oxidative stress.
research Risk Analysis of Lurasidone in Patients with Schizophrenia and Bipolar Depression
In this study, researchers analyzed lurasidone's risk profile for treating schizophrenia and bipolar depression, identifying unlisted adverse reactions like hypersexuality, restless leg syndrome, thrombocytopenia, and telogen effluvium, which show probable or possible correlations with the drug.
research FEATURES OF THE COURSE OF LICHEN PLANOPILARIS IN MEN
This study discusses clinical cases of Lichen Planopilaris in men that were initially misdiagnosed and inadequately treated, resulting in significant irreversible hair loss.
research LB1667 Successful treatment of rare linear lichen planopilaris with ixekizumab
This study reports that a patient with rare linear lichen planopilaris experienced complete hair regrowth after 12 weeks of treatment with the antibody ixekizumab, suggesting it as a potential targeted therapy.
research Metabolic disease with autoimmune phenomena: 2 cases of SLE-like disease in young children diagnosed with lysinuric protein intolerance
This study reports that the symptoms and immunological findings in two children with diverse autoimmune-like conditions were ultimately attributed to lysinuric protein intolerance, confirmed by genetic analysis in one child.
research Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation
This study demonstrates that Puerariae Lobatae Radix may regulate skin lipid metabolism by inhibiting sebaceous gland growth and reducing triglyceride secretion, highlighting its therapeutic potential for sebaceous gland-related conditions.
research Eucommia ulmoides Bark Extract Attenuates Oxidative Damage and H2O2-Induced Hair Follicle Suppression in Cellular and Mouse Models
This study found that Eucommia ulmoides bark extract shows potential antioxidant and hair follicle-support properties in vitro and in vivo, but further validation is needed to confirm these effects.
research Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series
This case report found that a novel botanical treatment halted disease progression and promoted hair regrowth in four patients with lichen planopilaris, indicating potential for use as a safe alternative therapy.
research Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart
This study concluded that dilated cardiomyopathy in Ctsl-deficient mice is mainly due to the lack of cathepsin L in cardiomyocytes, with additional heart stress from the fur defect.
research Regulatory mechanisms of LGR4 on cancer and cancer stem cell properties
This review discusses the role of LGR4 in tumors, highlighting its involvement in cancer progression, metastasis, and chemotherapy resistance, as well as its regulatory effects on tumor stem cell self-renewal and stem cell characteristics, based on multiple recent studies.
research Impaired turnover of autophagolysosomes in cathepsin L deficiency
This study found that mice deficient in the enzyme cathepsin L exhibited impaired degradation of autophagolysosomal content, leading to an accumulation of large, abnormal vesicles in various tissues.
research Novel lysophosphoplipid receptors: their structure and function
This review summarizes recent discoveries of GPCRs for lysophosphatidylserine and lysophosphatidylinositol, detailing their roles as lipid mediators, but reports no new experimental results.
research 18β‐Glycyrrhetinic acid: its core biological properties and dermatological applications
This review discusses the biological properties of 18β‐glycyrrhetinic acid derived from licorice root, highlighting its potential anti-inflammatory, antioxidant, and antimicrobial benefits in treating dermatological disorders, and reports no new experimental results.
research Lactate in skin homeostasis: metabolism, skin barrier, and immunomodulation
This study highlights emerging research on lactate's biological roles in skin health, emphasizing its function as a signaling molecule that regulates skin barrier and immunity, and notes its therapeutic potential for skin conditions such as tumors and inflammatory diseases.
research Anti-androgenic Activity of Myricae Cortex. Isolation of Active Constituents from Bark of Myrica rubra.
This study found that the aqueous ethanol extract of Myricae Cortex demonstrated in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic effects in mouse and hamster models.
research The effect of glycyrrhizic acid and aqueous licorice extract on hair growth retardation : in vitro mechanistic and efficacy studies in human
This study found that gels containing glycyrrhizic acid and aqueous Glycyrrhiza glabra extract significantly reduced underarm hair growth in terms of area, thickness, length, and number compared to their gel bases.
research iε-(γ-Glutamyl) lysine cross-linkage in citrulline-containing protein fractions from hair
Specific cross-linkages help make hair proteins stable and strong.
research Systems pharmacology identifies dermal papilla–specific transcriptomic reversal of androgenetic alopecia by lithium–zinc pathway convergence
This study found that the combination of lithium and zinc produced a statistically significant transcriptomic rescue across three datasets, with the strongest signal observed in a DP-enriched model, suggesting potential efficacy in targeting DP-specific pathways.
research Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice
This study found that biallelic LSS mutations lead to congenital hypotrichosis and cataracts, with each tissue-specific loss of function observed in mouse models.
research Outbreak of recombinant lumpy skin disease virus in yaks: high mortality and systemic pathogenesis in Qinghai-Tibet Plateau yak herds
This study suggests that recombinant Lumpy Skin Disease Virus strains pose a severe threat to yaks in the Qinghai-Tibet Plateau, causing high mortality and emphasizing the need for targeted control strategies.
research Potential Antioxidant and Wound Healing Effect of Nano-Liposol with High Loading Amount of Astaxanthin
Nano-liposol with astaxanthin may improve antioxidant and wound healing effects.
research Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior
The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.
research Strange cutaneous abnormalities and polyposis in an Asiatic man
This report documents a case of Cronkhite-Canada Syndrome in a 56-year-old Laotian man, who successfully improved with vitamin supplementation and medical treatment after experiencing weight loss, alopecia, and gastrointestinal polyposis.
research Lysophosphatidic acid and signaling in sensory neurons
This review discusses lysophosphatidic acid's role in neuropathic pain and cholestatic itch, highlighting its complex signaling pathways, but reports no new clinical results.
research Manfaat Buah Murbei sebagai Terapi Adjuvan Obesitas
This literature review concludes that mulberry, with its rich anthocyanin, phenolic, and antioxidant content, may serve as an effective adjuvant therapy for preventing and managing obesity by reducing body fat levels.
research The Pharmacological Potential of Bioactive Components of Zizypus jujuba Seeds: A Review
In this review, the authors highlighted the medicinal potential of Ziziphus jujuba seeds, emphasizing their antioxidant, antimicrobial, and anti-inflammatory properties, and called for further research to better understand their therapeutic effects and mechanisms.
research In Vitro Evaluate the Antiproliferative Impact of Cnicus Benedictus L. Leaves Methanolic Extract on Cervical Cancer
This study found that methanolic extract from Cnicus Benedictus leaves inhibits the growth of human cervical cancer cells in vitro and selectively targets cancer cells over normal cells, suggesting potential safety in its efficacy.