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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Early recognition and management of connective tissue diseases like lupus are crucial in young patients.

Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.

Hair restoration surgery can be safely done without major bleeding in patients on antithrombotic therapy, and these drugs shouldn't be stopped before surgery.

Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.

Classical PCOS types A and B are most common and linked to higher health risks.

Metformin is less effective in men with early-onset hair loss.

Hair loss may indicate higher heart risk and metabolic issues.

Higher doses of oestradiol implants improve bone density in postmenopausal women.

Spironolactone may cause sexual pain and arousal issues in women, which can improve after stopping the drug and using hormone cream.

Women with excessive hair growth or polycystic ovary disease may more often carry a gene variant for 21 hydroxylase deficiency.

Flibanserin's effectiveness for low sexual desire in premenopausal women may vary based on hormone levels, with normal hormone levels showing better responses.

Women with severe acne, hirsutism, and androgenic alopecia often have higher levels of certain androgens, but the specific pattern can't be predicted just by looking at symptoms.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Minoxidil, propranolol, and furosemide effectively control severe hypertension, but may cause sodium retention.

A study found that minoxidil can damage the hearts of dogs and pigs, cautioning its use in humans.

Teriflunomide effectively reduces relapses and disability in MS and has a manageable safety profile.

Combining platelet-rich plasma therapy with low dose oral minoxidil improved hair growth in men with hair loss, with slightly higher satisfaction at the higher minoxidil dose.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Isotretinoin can raise CPK levels, so patients need monitoring, especially before surgery.

PCOS is a common hormonal disorder with symptoms like irregular periods and excess hair growth, managed with lifestyle changes and medications.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

Thoracic medial branch block may be a simpler and effective alternative to thoracic vertebroplasty for pain management.

Follicular unit hair transplantation is better than Miniflap Hair Restoration due to less scarring and more natural results.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Toxic Shock Syndrome progresses quickly, often involves multiple organs, and is linked to Staphylococcus aureus toxins, with treatment options available but diagnostic challenges remaining.

Hair loss in young men linked to higher risk of insulin resistance and metabolic issues.

Finasteride effectively reduces hair growth in women with polycystic ovary syndrome or idiopathic hirsutism.