Clinical Aspects and Spectrum of Illness of Toxic Shock Syndrome: Overview
January 1989
in “
Clinical Infectious Diseases
”
TLDR Toxic Shock Syndrome progresses quickly, often involves multiple organs, and is linked to Staphylococcus aureus toxins, with treatment options available but diagnostic challenges remaining.
The document from 1989 provides an overview of Toxic Shock Syndrome (TSS), detailing its rapid onset, progression, and the involvement of Staphylococcus aureus toxins in its pathophysiology. It describes the typical multisystem organ involvement and distinctive dermatologic symptoms, noting a high recurrence rate in menstruation-associated TSS cases. The paper emphasizes the diagnostic challenges due to the lack of specific tests and the presence of S. aureus in asymptomatic individuals. Treatment strategies include antimicrobial therapy, supportive care, and the potential use of Intravenous immune globulin (IVIG), although its use is not yet standardized. The document calls for further research to better understand the toxins and mechanisms of TSS and to improve diagnosis and management.
