The Dose-Response of Percutaneous Estradiol Implants on the Skeletons of Postmenopausal Women

The document reviewed several studies, including one that investigated the effects of percutaneous oestradiol implants on the bone density of postmenopausal women. This particular study included 45 women who were randomized to receive either 25 mg, 50 mg, or 75 mg oestradiol implants. The results showed a significant correlation between increased plasma oestradiol levels and bone density gains at the lumbar spine and proximal femur. Additionally, it was found that maintaining plasma oestradiol levels above 300 pmol/l prevented bone density loss at clinically significant sites. Other topics in the document, such as hormonal profiles in hyperandrogenic women, treatment of hyperprolactinemic amenorrhea, breast cancer risks associated with oral contraceptives, and methods for inducing early abortion, were not related to hair loss, alopecia, or hair growth.