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Different treatments for PCOS focus on the specific symptoms, with weight loss and lifestyle changes being important.

Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.

Surgery to lower high testosterone in postmenopausal women with certain ovarian tumors doesn't significantly affect their metabolism.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

A 5 mg dose of transdermal testosterone cream effectively restores testosterone levels in postmenopausal women.

Changing the diet of mice lacking the enzyme CBS can affect symptoms related to the genetic condition.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

Certain gene patterns in breast cancer are linked to how active hormone receptors are and could affect patient survival.

We need better ways to test and understand SARMs to make safer and more effective treatments.

A rare endocrine disorder, APS 1, was diagnosed in a 26-year-old man in Bangladesh.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Testosterone therapy can improve sexual function in women but long-term safety is unclear.

A new gene variant causes glucocorticoid resistance in a mother and son.

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.

The document concludes that proper diagnosis and combined treatments are key for hirsutism management, and weight loss may help overweight patients.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Women with nonclassic 21-hydroxylase deficiency can have successful pregnancies through IVF, with certain factors affecting their chances.

Androgen suppression therapy (AST) doesn't significantly lower bladder cancer risk, but using finasteride, a type of AST, might reduce it. AST decreases recurrence-free survival but doesn't affect overall survival or progression-free survival. More research is needed to understand AST's benefits.

The document explains how male reproductive hormones work and affect the body.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Lower SHBG levels may increase the risk of PCOS.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

New therapies are being developed that target integrin pathways to treat various diseases.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.