Table 1

    December 2021
    Image of study
    TLDR Androgen suppression therapy (AST) doesn't significantly lower bladder cancer risk, but using finasteride, a type of AST, might reduce it. AST decreases recurrence-free survival but doesn't affect overall survival or progression-free survival. More research is needed to understand AST's benefits.
    This systematic review and meta-analysis incorporated 18 studies involving 414,007 male patients to examine the effect of androgen suppression therapy (AST) on bladder cancer incidence and patient outcomes. The results indicated that AST did not significantly lower the risk of bladder cancer. However, a subgroup analysis revealed that patients taking finasteride, a type of AST, had a reduced risk of bladder cancer. AST was found to decrease recurrence-free survival in bladder cancer patients, but it did not significantly affect cancer-specific survival, overall survival, or progression-free survival. The authors concluded that more research is needed to fully understand the benefits of AST, particularly in different types of bladder cancer and across different racial groups.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 21 months on topical minoxidil and full HRT

      in Transgender  214 upvotes 7 months ago
      The conversation is about a transgender individual's experience with hair regrowth using topical minoxidil and hormone replacement therapy (HRT), expressing concern about the slow growth and thin appearance of their hair. Some responses encourage patience and highlight the variability of results, while others discuss the role of HRT and its effects.

      community Is Pyrilutamide the real deal and if so when will it actually be available?

      in Chat  21 upvotes 2 years ago
      Pyrilutamide, a potential hair loss treatment that is currently in development and may be available soon; an androgen receptor degrader which is also being developed as a potential treatment for hair loss; and the comparison between Pyrilutamide, finasteride, minoxidil, and RU58841.

      community DHT/Testosterone levels in scalp Fin VS Dut.

      in Finasteride/Dutasteride  60 upvotes 5 months ago
      Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

      community Are these all the anti androgen products?

      in Treatment  6 upvotes 1 year ago
      The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

      community Binding affinity of pyrilutamide!

      in Update  167 upvotes 2 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

    Similar Research

    5 / 1000+ results