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Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

Most Recessive Dystrophic Epidermolysis Bullosa patients with a specific mutation likely have Sephardic ancestry from about 500 years ago.

A specific ATR gene mutation is linked to a hereditary oropharyngeal cancer syndrome.

Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.

Adding a second method to PROTACs could improve cancer treatment.

Netherton syndrome can cause severe and chronic vulvovaginal symptoms that may improve with continuous oral contraceptives.

Targeted cytokine treatments may help with alopecia areata, but more research is needed.

Changes in KRT17 gene activity linked to wool production in Angora rabbits.

Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.

Zebrafish are useful for studying and developing treatments for human skin diseases.

New therapies are being developed that target integrin pathways to treat various diseases.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

Baricitinib significantly improved hair regrowth and skin condition in a 14-year-old with alopecia areata and atopic dermatitis.

When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.

Disrupting β-catenin signaling in certain cells causes anorectal malformations.

Studying rare genetic disorders can help us understand and treat common diseases better.

The study concludes that mutations in the AEBP1 gene can cause a form of Ehlers-Danlos syndrome and should be considered in diagnosis.

Understanding where cancer cells come from helps create better prevention and treatment methods.

A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.

Tandem repeats significantly influence hair color, especially darker shades, across different ancestries.

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

Inactive hair follicle stem cells help prevent skin cancer.

The document concludes that Nonclassic Congenital Adrenal Hyperplasia requires personalized treatment plans to manage symptoms and fertility, with glucocorticoids being a common therapy.

A boy's skin fragility and sparse hair were caused by a genetic mutation affecting skin cell adhesion.

Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.

Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.