August 2024 in “Current Protocols” The C3H/HeJ mouse model is useful for studying and testing treatments for alopecia areata.
222 citations,
August 2009 in “Experimental Dermatology” Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.
164 citations,
February 2010 in “Journal of Cell Science” Human dermal stem cells can become functional skin pigment cells.
56 citations,
September 2010 in “Veterinary pathology” Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.
37 citations,
November 2017 in “Medical Sciences” Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.
16 citations,
November 2022 in “eLife” Both gene and non-gene areas of DNA evolved to make some mammals hairless.
10 citations,
June 2016 in “Cell Transplantation” Sebaceous glands can help harvest hair follicle stem cells to regenerate skin and hair.
4 citations,
October 2022 in “Genes” Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.
1 citations,
March 2023 in “Frontiers in Cardiovascular Medicine” A specific gene variant is linked to heart disease, increased heart muscle, curly hair, and thick skin on palms and soles.
Hairlessness in mammals is due to complex genetic changes in both genes and regulatory regions.
April 2018 in “Veterinary Pathology” Tigers had a skin condition causing hair loss and inflammation, but the cause is unknown and treatment didn't work.
53 citations,
January 2013 in “Journal of toxicologic pathology” The project created a standardized system for classifying skin lesions in lab rats and mice.
45 citations,
August 2018 in “Haematologica” Macrophage iron release is crucial for hair growth and wound healing.
33 citations,
January 2018 in “Blood” Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.
31 citations,
August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
29 citations,
November 2011 in “Cell stress & chaperones” Quercetin effectively treated and prevented hair loss in mice.
26 citations,
December 2013 in “Seminars in cell & developmental biology” Skin varies in thickness, color, and features due to complex genetic and cellular processes.
11 citations,
May 2012 in “Genesis” Bmpr2 and Acvr2a receptors are crucial for hair retention and color.
8 citations,
June 2022 in “Scientific Reports” LGR5 is a common marker of hair follicle stem cells in different animals and is important for hair growth and regeneration.
5 citations,
March 2022 in “Frontiers in Medicine” PRP is effective for treating hair loss, especially with other treatments.
3 citations,
July 2023 in “Cells” MG53 helps reduce skin damage caused by nitrogen mustard.
2 citations,
August 2019 in “Journal of skin and stem cell” The study concludes that regulating apoptosis could lead to new treatments for various skin and hair conditions.
1 citations,
February 2023 in “ACS Biomaterials Science & Engineering” The new microwell device helps grow more hair stem cells that can regenerate hair.
1 citations,
May 2021 in “BMC Proceedings” The document concludes that more research is needed to reduce frequent hospital visits, addiction medicine education improves with specific training, early breast cancer surgery findings are emerging, nipple smears are not very accurate, surgery for older melanoma patients doesn't extend life, a genetic condition in infants can often be treated with one drug, doctors are inconsistent with blood clot medication, a certain gene may protect against cell damage, muscle gene overexpression affects many other genes, and some mitochondrial genes are less active in mice with tumors.
August 2024 in “Applied Sciences” Plant extracts may help prevent or reverse hair graying.
April 2024 in “Journal of translational medicine” MJ04, a new compound, effectively promotes hair growth and is a potential topical treatment for hair loss.
February 2024 in “International Journal of Molecular Sciences” Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.
August 2023 in “Dermatology and Therapy” Experts recommend personalized treatment plans for best outcomes in managing Alopecia Areata.
October 2022 in “Frontiers in Genetics” The research found new potential mechanisms in mouse hair growth by studying RNA interactions.
5 citations,
January 2010 in “The anatomical record” Most dogs have hair whorls on their chest and limbs, with shelter dogs and short-haired dogs having more chest whorls.