S-1 Induced Discoid Lupus Erythematosus-Like Lesions and Long-Term Complete Response for Para-Aortic Lymph Node Recurrence of Pancreatic Ductal Adenocarcinoma: A Case Report

    June 2018 in “ Surgical Case Reports ”
    Ryosuke Yamaga, Koji Tezuka, Shuichiro Sugawara, Toshihiro Watanabe, Ichiro Hirai, Tamio Suzuki, Wataru Kimura
    Image of study
    TLDR S-1 treatment led to a complete response in pancreatic cancer with manageable side effects.
    In 2018, a 65-year-old Japanese man with recurrent pancreatic ductal adenocarcinoma experienced a complete response to S-1 monotherapy, despite developing discoid lupus erythematosus (DLE)-like skin lesions. The patient's CA19-9 levels decreased and the lymph node metastasis shrank within the first month of treatment. He continued the therapy at a reduced dose for 41 months, with medical management of the skin lesions, and remained free of recurrence or metastasis for 113 months post-surgery. The case highlighted the potential for S-1 therapy to be effective even with DLE-like lesions, provided that the dosage is managed and skin lesions are treated. The patient also developed mesangial proliferative glomerulonephritis, possibly related to S-1. Regular monitoring of proteinuria and renal function was recommended for patients with DLE-like drug eruptions during S-1 treatment.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 106 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community HMI 115 Phase 2 - Leaked pics from Discord

      in Research/Science  361 upvotes 6 months ago
      The conversation discusses HMI 115, a new hair loss treatment with promising results, showing a significant increase in hair density after two months. Some users are skeptical, while others are hopeful for its release and potential affordability.

      community We need to create a Discord KX-826 Monotheray group:

      in Research/Science  29 upvotes 2 years ago
      The conversation is about starting a Discord group for people using KX-826 as their only treatment for hair loss, excluding those who are not serious or use multiple treatments. Someone agrees with the idea but mentions "GP :3," which is unclear.

    Similar Research

    5 / 955 results