Evidence-Based Data on Duration of Baricitinib Treatment for Severe Alopecia Areata

January 2025 in “ SKIN The Journal of Cutaneous Medicine ”

Brett King, Maryanne M. Senna, Manabu Ohyama, Rodney Sinclair, Najwa Somani, Yves Dutronc, Na Lü, Yun-Fei Chen, Jakub Jedynak, Andrew Buchanan, Bianca Maria Piraccini

baricitinib alopecia areata SALT score BRAVE AA1/AA2 trials

TLDR Baricitinib treatment for severe alopecia areata shows significant improvement by 52 weeks, especially in very severe cases.

The study evaluates the optimal duration of baricitinib treatment for severe alopecia areata (AA) using data from the BRAVE AA1/AA2 phase 3 trials. Patients were treated with 4 mg of baricitinib daily for up to 52 weeks, and their responses were assessed based on baseline severity and episode duration. For those with severe AA (SALT score 50-94), improvement (SALT30) was observed between 24-36 weeks, with 75% achieving a SALT score ≤20 by week 52 if their episode was <4 years, compared to 65% for episodes >4 years. In very severe cases (SALT score 95-100), improvement continued through 52 weeks, suggesting that treatment duration should be tailored to baseline severity, with at least 1 year needed for very severe cases to see significant effects.

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community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 1 year ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

community Lilly to seek first approval of an autoimmune drug for hair loss

in Research/Science 19 upvotes 3 years ago

Eli Lilly's drug baricitinib showed effectiveness in treating alopecia areata, with higher doses resulting in significant hair regrowth compared to placebo. The treatment is not for male pattern baldness.

community Anyone else taking Litfulo (ritlecitinib) to treat their alopecia?

in Treatment 5 upvotes 1 year ago

A user diagnosed with Alopecia Areata started using Litfulo (ritlecitinib), kenalog shots, and mometasone furoate 0.1%. They shaved their head and are seeking others' experiences with Litfulo.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Olumiant active ingredient Baricitinib

in Research/Science 1 upvotes 2 years ago

The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

community Anyone heard of or have experience using baricitinib?

in Research/Science 1 upvotes 1 year ago

The conversation is about baricitinib, a medicine that can help with hair loss, and why it isn't more popular or widely discussed. No specific experiences with the treatment were shared.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.