Additional Intraoperative Autologous-Derived Platelet-Rich Stroma to Transanal Flap Repair for the Treatment of Cryptoglandular Transsphincteric Fistulas in a Tertiary Referral Center: Long-Term Outcomes of a Prospective Pilot Study

    January 2025 in “ Bioengineering ”
    Michiel T. Bak, Caroline D.M. Witjes, Roy S. Dwarkasing … Oddeke van Ruler
    Studysummary This study evaluated the long-term effects of combining autologous platelet-rich stroma injection with transanal advancement flap repair for cryptoglandular transsphincteric fistulas and found that it resulted in primary clinical closure and radiological healing in a high percentage of patients, with low recurrence rates.
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    Research cited in this study 4

    1. Addition of Platelet-Rich Plasma to Endorectal Advancement Flap Repair Does Not Enhance Healing of Cryptoglandular Transsphincteric Fistulas Diseases of the Colon & Rectum · 2024
    2. Mechanical Fractionation of Adipose Tissue: A Scoping Review of Procedures to Obtain Stromal Vascular Fraction Bioengineering · 2023
    3. Efficacy and Safety of Autologous Adipose-Derived Stromal Vascular Fraction Enriched with Platelet-Rich Plasma in Flap Repair of Transsphincteric Cryptoglandular Fistulas Techniques in Coloproctology · 2021
    4. Introducing Platelet-Rich Stroma: Platelet-Rich Plasma and Stromal Vascular Fraction Combined for the Treatment of Androgenetic Alopecia Aesthetic Surgery Journal · 2018