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Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

VDR regulation varies by tissue and is crucial for its biological functions.

Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

TGF-β2 plays a key role in human hair growth and development.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

Men with hair loss may lack zinc, copper, and vitamin D; supplements could help.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.

Testosterone is crucial for development, growth, and various body functions in mammals.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.

Neuregulin3 affects cell development in the skin and mammary glands.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Vitamin D is important for bones, hair, blood pressure, and breast development.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Two rare genetic diseases cause severe rickets in children due to defects in vitamin D metabolism.

Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.