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Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

Vitamin D is important for skin cell growth and health, and its active form and receptor play key roles in skin and hair processes.

Bexarotene 1% topical gel helped some patients with alopecia areata regrow hair.

Hair color is determined by melanin produced and transferred in hair follicles.

Chinese domestic goats have unique genetic traits due to domestication and geographic isolation.

A new mutation in the ST14 gene broadens the understanding of ichthyosis-hypotrichosis syndrome.

Regenerated hairs can regain their color if the wound occurs during a certain stage of hair growth, and this process is helped by specific skin cells and proteins.

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

Psoriasis may be chronic because it lacks certain immune system controls that prevent overreaction.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Finasteride reduces alcohol withdrawal effects, especially in female mice.

Testosterone is crucial for development, growth, and various body functions in mammals.

Researchers developed reliable models to predict how well certain compounds bind to androgen receptors, emphasizing the importance of atomic electronegativity.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

Fat tissue stem cells may help increase hair growth.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

PTHrP and its receptor can control blood vessel growth and hair development in mouse skin.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.