April 2017 in “Journal of Investigative Dermatology” In this study, higher plasma leptin levels were associated with increased risk and severity of androgenetic alopecia in men, but further research is needed to understand the clinical implications.
November 2025 in “ACS Omega” This study found that incorporating Canavalia ensiformis lectin into alginate and carboxymethylcellulose films enhanced angiogenic factor expression, suggesting these biopolymer films could be an effective alternative for wound treatment.
47 citations
,
April 2012 in “Analytical and Bioanalytical Chemistry” 107 citations
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May 1999 in “Archives of Dermatological Research” In this study, the immunohistochemical and lectin binding profiles of basal cell carcinoma closely resembled those of the outer root sheath of vellus hair follicles, suggesting a potential histochemical relationship.
36 citations
,
April 2019 in “Journal of Herbal Medicine” This review discusses the therapeutic potential of Ganoderma lucidum's secondary metabolites, noting their diverse health benefits, such as anticancer and antioxidant effects, without presenting new experimental results.
8 citations
,
May 2017 in “Current traditional medicine” This review explores the phytochemistry and phytopharmacology of Urtica dioica but reports no new experimental findings, focusing on its traditional uses and range of bioactive constituents.
February 2019 in “Mintage journal of pharmaceutical and medical sciences” This article reviews the phytochemical and pharmacological properties of Erythrina variegata but reports that effective anti-alopecia compounds have not yet been identified, suggesting further research is needed.
December 2011 in “URMIA MEDICAL JOURNAL” This study concluded that the expression of specific glycoconjugate terminal sugars is developmentally regulated during rat hair follicle morphogenesis.
506 citations
,
March 2005 in “The Journal of Clinical Endocrinology and Metabolism” This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.
363 citations
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May 2006 in “Current Opinion in Psychiatry” This review highlights that medical complications, notably in anorexia nervosa, are common and often serious in patients with eating disorders, affecting multiple organ systems.
218 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.
155 citations
,
March 2006 in “The American Journal of Medicine” This study found that young women with polycystic ovary syndrome have altered endothelial function associated with insulin resistance and lower adiponectin levels.
105 citations
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February 2011 in “The Journal of Clinical Endocrinology & Metabolism” Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.
74 citations
,
October 2015 in “Experimental Dermatology” This study found that sebocytes in human skin express and secrete certain adipokines, suggesting they might play active roles in skin inflammation rather than just being targets.
69 citations
,
November 2010 in “Middle East Fertility Society Journal” This review discusses the multifactorial origins and pathophysiology of PCOS and highlights the effectiveness of lifestyle modifications as a first-line intervention, reporting no new research results.
32 citations
,
January 2007 in “KARGER eBooks” This review discusses severe insulin resistance syndromes, highlighting their diagnostic challenges, potential novel therapies like leptin replacement, and suggests metformin and lifestyle changes in its absence; no new clinical results are reported.
31 citations
,
November 2020 in “International journal of molecular sciences” This review discusses the role of adipokines in skin physiology and pathology, suggesting they may influence skin conditions and diseases through interaction with various skin cell types, but reports no new clinical results.
30 citations
,
January 2013 in “Obesity Surgery” This review summarizes the effects and complications of bariatric surgery on skin, noting it can alter existing skin conditions like psoriasis and trigger new dermatoses, but provides no new clinical results.
23 citations
,
September 2011 in “Journal of Dermatological Science” This study explored the effects of a new narrow-band red LED light on hair growth in mice, showing potential benefits compared to existing laser therapies.
20 citations
,
July 2013 in “International Journal of Dermatology” This review addresses obesity-related dermatoses and highlights the potential increased risk of skin cancer associated with obesity; it presents no new clinical findings.
18 citations
,
January 2020 in “Journal of Clinical Research in Pediatric Endocrinology” This review discusses the pathophysiology, diagnosis, and management of functional hypothalamic amenorrhea in adolescent girls and reports no new clinical results.
14 citations
,
October 2020 in “Journal of ethnopharmacology” This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.
13 citations
,
October 2024 in “Scientific Reports” In this study using data from young women in West Bengal, India, the researchers identified that leptin signaling impairment, insulin resistance, and specific gene mutations significantly contribute to PCOS, with obesity commonly manifesting in affected individuals.
12 citations
,
October 2018 in “Aging male/The aging male” This study found that prostate cancer aggressiveness in men with obesity is associated with changes in age, BMI, testosterone, and estradiol levels, and that adipocyte-secreted molecules increase cancer cell aggressiveness in vitro.
12 citations
,
October 2004 in “Experimental Gerontology” This review summarizes how common polymorphisms in androgen and estrogen receptor genes may influence aging-related symptoms and diseases in men, but it reports no new clinical results.
5 citations
,
August 2015 in “Bioscience, Biotechnology, and Biochemistry” In this study, ob/ob mice were found to have a prolonged telogen hair cycle phase from 10 to 24 weeks, suggesting their potential as a model for studying telogen effluvium.
4 citations
,
February 2022 in “Nutrients” In this study, saponins from Korean red ginseng were found to protect against the harmful effects of airborne particulate matter on human skin cells by reducing oxidative stress, inflammation, leptin expression, and melanin production.
3 citations
,
May 2023 in “Biomedicines” This article reviews the immunometabolic mechanisms linking polycystic ovary syndrome to infertility and stresses the need for interdisciplinary approaches to treat PCOS-related fertility issues; it reports no new clinical results.
3 citations
,
December 2017 in “Clinical and Experimental Dermatology” In this case study, researchers observed reversible scalp hair loss associated with centrifugal lipodystrophy, potentially linked to altered leptin expression in inflamed adipose tissue.
3 citations
,
March 2017 in “Iraqi Journal of Pharmaceutical Sciences” This study found that combining silymarin with metformin improved hormone levels and ovulation rate in patients with polycystic ovary syndrome more effectively than either treatment alone.