Centrifugal Lipodystrophy of the Scalp Manifesting as Centrifugal Lipodystrophic Alopecia

The document described a rare case of centrifugal lipodystrophy (CLD) of the scalp in a young East Asian patient, which led to reversible hair loss in a ring-shaped pattern. The hair loss expanded outward while the central area showed regrowth. Immunohistochemical analysis revealed reduced leptin expression in inflamed adipose tissue, which is linked to the anagen phase of hair growth. Recovery of leptin expression was noted in healed areas, suggesting that changes in leptin expression in adipose tissue might cause reversible hair loss.