TLDR Reversible hair loss in a ring pattern on the scalp may be linked to changes in leptin levels in fat tissue.
The document described a rare case of centrifugal lipodystrophy (CLD) of the scalp in a young East Asian patient, which led to reversible hair loss in a ring-shaped pattern. The hair loss expanded outward while the central area showed regrowth. Immunohistochemical analysis revealed reduced leptin expression in inflamed adipose tissue, which is linked to the anagen phase of hair growth. Recovery of leptin expression was noted in healed areas, suggesting that changes in leptin expression in adipose tissue might cause reversible hair loss.
41 citations,
November 2013 in “Experimental Dermatology” Leptin, a hormone, is important for starting hair growth.
34 citations,
December 2011 in “The Journal of Dermatology” A unique type of lupus panniculitis causes reversible hair loss on the scalp in East Asians.
42 citations,
May 2016 in “Annual Review of Cell and Developmental Biology” Fat cells are important for tissue repair and stem cell support in various body parts.
77 citations,
March 2014 in “Cold Spring Harbor Perspectives in Medicine” Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.
499 citations,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
136 citations,
September 2019 in “Journal of Clinical Investigation” Dermal adipose tissue in mice can change and revert to help with skin health.
15 citations,
February 2021 in “Frontiers in immunology” Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.
