May 2022 in “Journal of Cutaneous Immunology and Allergy” This case report highlights that asymptomatic domestic cats can transmit Microsporum canis, leading to tinea capitis in humans, as seen in a four-year-old girl in the study.
November 2021 in “CRC Press eBooks” This review discusses the genetic and metabolic factors influencing hair pigmentation, as well as conditions leading to hypo- or depigmented hair, and reports no new experimental findings.
November 2021 in “European Heart Journal Supplements” This case report describes a woman with systemic lupus erythematosus who developed chronic thromboembolic pulmonary hypertension, leading to improved right heart function after treatment with diuretics, anticoagulants, corticosteroids, and immunosuppressants.
September 2021 in “World journal of urology” The correction states that the label change for Finasteride was in 2012, leading to more reports of side effects from non-healthcare people.
July 2021 in “British Journal of Dermatology” The pandemic likely caused delays in skin cancer assessments, leading to fewer early diagnoses and thicker melanomas.
June 2020 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, the authors observed that controlled microflora in gnotobionts leads to delayed maturation of T-dependent lymphocytes in the thymus, affecting cellular immunity reactions.
In this study, researchers observed that oncogenic HrasG12V in single murine epidermal cells leads to an initial increase in progenitor cell renewal, but ultimately results in balanced cell fate choices that limit clone growth.
September 2018 in “Research in medical & engineering sciences” This personal account describes the author's experience of being scammed by a fraudulent digital marketing company promising sales leads from a health marketing campaign.
April 2018 in “Journal of Investigative Dermatology” This study found that the loss of transcription factor Ovol2 in epidermal and hair follicle stem cells leads to migration defects, which are partially improved by deleting the EMT-inducing Zeb1.
This study developed and validated an optimized culture method for dermal papilla cells, leading to the establishment of an immortalized cell strain called iDP6, which resembles primary DP cells in key characteristics.
September 2017 in “Journal of Investigative Dermatology” LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.
April 2012 in “Cancer Research” In this study, mouse models with EGFR deficiency showed that disrupted hair follicle cycling leads to increased mast cell numbers and inflammation, suggesting EGFR's role in managing hair cycle transitions and preventing folliculitis.
January 2011 in “Reactions Weekly” Long-term use of minoxidil may cause hair follicles to transform into noticeable terminal hairs, leading to trichostasis spinulosa.
July 2008 in “Planta Medica” This study found that Acanthus montanus leaves' aqueous extract is a developmental toxicant in rats, leading to several adverse effects on offspring when used during pregnancy.
January 2008 in “대한미용학회지” This study reports that prolonged UV irradiation causes progressive damage to the hair's keratin structure, leading to increased surface roughness, cuticle destruction, and decreased tensile strength in young women’s hair.
The authors of this study concluded that higher calcium levels in hair may indicate early metabolic changes leading to osteopenia or osteoporosis in menopausal women, even before detectable by standard DEXA imaging.
January 2005 in “Journal of Marine Fisheries” Female pattern hair loss is caused by genetics and hormones, leading to hair thinning in women.
January 2005 in “Chinese Journal of Integrated Traditional and Western Nephrology” This study found that systemic lupus erythematosus in aging patients often presents with atypical clinical manifestations, leading to more frequent misdiagnosis, yet these patients may respond better to treatment.
January 2004 in “Giornale di Metafisica: revista bimestrale di filosofia” This study suggests that increased Wnt signaling may promote excessive differentiation of melanocytes, leading to exhaustion of melanocyte stem cells and hair graying in aged mice.
January 2004 in “Laboratory Animal Science and Administration” This study found that the hairless mutant gene in C 57BL/6 mice affects the hair follicle cycle and leads to early thymus degeneration and distinct skin changes.
December 1997 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” This study concluded that low energy laser therapy may effectively complement classical treatment for scalp alopecia, leading to faster results, although long-term maintenance still requires ongoing classical therapy.
January 2022 in “Current Enzyme Inhibition” This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.
January 2003 in “Journal of Dermatology and Venereology” Female pattern hair loss in women is caused by hormones and genetics, leading to hair thinning, with various treatments available.
471 citations
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October 2012 in “Cellular and Molecular Life Sciences” This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.
414 citations
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August 2005 in “Nature” In this study, researchers discovered that activating TERT in mouse skin epithelium triggers dormant hair follicle stem cells, leading to rapid hair growth, through a pathway independent of telomere extension.
343 citations
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March 2016 in “Nature Communications” This study found that IL-17A-producing γδ T cells play a key role in bone fracture healing by promoting bone formation, with deficiencies leading to impaired repair in mice.
333 citations
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March 2000 in “Proceedings of the National Academy of Sciences” In this study, researchers established that increased expression of the human GLI-1 gene in mouse skin leads to the development of tumors that closely resemble human basal cell carcinomas, without requiring additional mutations in the p53 or Ha ras genes.
277 citations
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July 2002 in “Molecular Endocrinology” In this study, homozygous VDR null mutant mice exhibited nonfunctional vitamin D receptors, leading to growth abnormalities and revealing the limited physiological importance of vitamin D pathways outside the classical receptor.
266 citations
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January 2016 in “Development” In this study, researchers found that YAP and TAZ, when localized in the nucleus of basal layer cells, are crucial for skin regeneration and hair growth, with their loss leading to slower cell proliferation, hair loss, and impaired wound healing in mice.
245 citations
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January 1998 in “Genes & Development” This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.