Polycystic Ovary Syndrome: An Endocrine Disorder

October 2013 in “ Springer eBooks ”

Joslyn S. Kirby

Polycystic Ovary Syndrome PCOS hyperandrogenism anovulation polycystic ovaries hirsutism acne androgen insulin-sensitizing agents metformin

Studysummary PCOS is a hormonal disorder causing infertility and menstrual problems, often linked to obesity and can lead to acne, treated with hormonal and insulin-sensitizing medications.

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Research cited in this study

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research Polycystic Ovary Syndrome and Acne

10 citations , January 2011 in “Skin therapy letter”

This review discusses treatments for acne in women with polycystic ovary syndrome due to androgen excess and reports no new clinical results.

research Ovarian Morphology and Prevalence of Polycystic Ovary Syndrome in Reproductive Aged Women With or Without Mild Acne

20 citations , June 2010 in “International Journal of Dermatology”

In this study, acne and hirsutism in women were associated with a higher prevalence of polycystic ovary syndrome compared to those without these conditions.

research Androgen Dependence of Hirsutism, Acne, and Alopecia in Women

105 citations , January 2009 in “Medicine”

This study found that ethinylestradiol and high-dose cyproterone acetate significantly reduced hirsutism scores and were effective for treating acne and alopecia in women with hyperandrogenism.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.

research Hirsutism and Acne in Polycystic Ovary Syndrome

169 citations , August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”

This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

This review discusses polycystic ovary syndrome, emphasizing its broad range of manifestations and associations with risks like type 2 diabetes and cardiovascular events, but reports no new clinical results.

research Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome

192 citations , September 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study suggests that metformin may be more effective than Dianette in treating moderate to severe hirsutism in women with PCOS, while also reducing markers of insulin resistance.

research The Evaluation and Management of Hirsutism

195 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”

This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.

research A Comparison of the Relative Efficacy of Antiandrogens for the Treatment of Acne in Hyperandrogenic Women

74 citations , August 2002 in “Clinical Endocrinology”

In this study, low doses of cyproterone acetate with ethinylestradiol were as effective as low-dose flutamide in reducing acne severity in hyperandrogenic women, while finasteride was less effective.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

633 citations , September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

This study observed that among a cohort of reproductive-aged women in the U.S., the prevalence of PCOS was about 4.0%, with no significant racial differences between White and Black women.

research Clinical, Ultrasound, and Hormonal Markers of Androgenicity in Acne Vulgaris

57 citations , August 1995 in “British Journal of Dermatology”

In this study, acne severity in females was strongly associated with inflammatory lesion count and moderately associated with androgens, especially DELTA 4 and DHEAS promoting acne and SHBG reducing it.

research Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial

165 citations , February 1994 in “Fertility and Sterility”

This study found that flutamide was more effective than spironolactone in reducing symptoms of hirsutism and related conditions in premenopausal women, with fewer discontinuations due to side effects.