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210-240 / 1000+ resultsresearch Questionnaire Modifications and Alternative Scoring Methods of the Dermatology Life Quality Index: A Systematic Review
This review categorizes 59 modifications of the Dermatology Life Quality Index across multiple studies, highlighting the need for further validation of these customized health-related quality of life tools in dermatology.
research The Dermatology Life Quality Index (DLQI) used as the benchmark in validation of 101 quality‐of‐life instruments: A systematic review
This review found that the DLQI is widely used as a benchmark in the development and validation of dermatology quality-of-life measures.
research Effect of laser diode light irradiation on growth capability of human hair follicle dermal papilla cells
This study observed increased proliferation and certain gene expressions in dermal papilla cells exposed to an 808 nm laser diode array at doses above 0.5 J/cm².
research 301 The Spectrum of PLEC Sequence Variants and Related Plectinopathies Including Novel Association with Epidermolysis Bullosa Pruriginosa
This study identified 15 Iranian patients with PLEC variants linked to various plectinopathies and highlighted a novel association between a homozygous nonsense variant in PLEC and a rare combination of disorders including EB pruriginosa, muscular dystrophy, and congenital myasthenic syndrome.
research A prospective, comparative evaluation of axillary hair removal with an 808-nm diode laser at different fluences
This study evaluated an 808-nm diode laser at different fluences for permanent axillary hair removal in Korean women and found that high-fluence treatment (14 J/cm2) effectively reduced hair density and thickness, with no significant difference in comfort compared to lower fluences.
research Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor
This study found that the L457(3.43)R mutation in the human luteinizing hormone receptor increases phosphodiesterase activity, reducing hormonal response despite elevated basal cAMP levels.
research Comparación de los efectos del D-004, imipramina y sertralina en el modelo de nado forzado en ratones Comparative effects of D-004, Imipramine and Sertraline in the forced swimming test in mice
This study found that D-004, a lipid extract from royal palm fruit, has a moderate antidepressant effect in mice, which may help treat depressive symptoms in patients with benign prostatic hyperplasia.
research 62339 Improvement in anxiety and depression in adult patients with severe alopecia areata treated with deuruxolitinib: Pooled data from the THRIVE-AA1 and THRIVE-AA2 Phase 3 trials
Deuruxolitinib improves anxiety and depression in severe alopecia areata patients.
research Ectodysplasin research—Where to next?
This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.
research Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy
This study found that nano-sized lipid particles improved the skin accumulation and retention of dexamethasone compared to a base cream, suggesting potential benefits for inflammatory skin disease treatment.
research 575 INTASYL self-delivering RNAi: A flexible platform to treat dermatological malignancies
INTASYL is a promising, adaptable RNAi technology for treating skin cancers.
research Identification of a novel homozygous LAMB3 mutation in a Chinese male with junctional epidermolysis bullosa and severe urethra stenosis: A case report
This case study reports a new LAMB3 mutation linked to junctional epidermolysis bullosa with severe urinary tract stenosis, outlining treatment challenges and expanding knowledge of EB-related urological complications.
research LB793 A phase 1, open-Label, single ascending dose study in healthy subjects of the safety, tolerability and pharmacokinetics of ASLAN004, a novel IgG anti-IL-13 receptor alpha 1 Inhibitor
ASLAN004 was safe and well-tolerated, supporting further development for treating certain diseases.
research The 800-nm diode laser irradiation induces skin collagen synthesis by stimulating TGF-β/Smad signaling pathway
This study concluded that the 800-nm diode laser is effective in enhancing skin structure and collagen expression via the TGF-β/Smad pathway, suggesting potential for non-ablative rejuvenation.
research Novel D323G mutation of DSG4 gene in a girl with localized autosomal recessive hypotrichosis clinically overlapped with monilethrix
This study reports that a homozygous A1103G mutation in DSG 4 is responsible for localized autosomal recessive hypotrichosis in a 2-year-old Chinese girl, resulting in reduced DSG 4 expression and hair defects.
research Enzalutamide/finasteride/goserelin/zoledronic-acid
research Multi-Target Aesthetic Enhancement with 1064 nm Q-Switched Nd:YAG Laser: Face and Body Hair Lightening, Pigment Clearance, and Skin Rejuvenation in Indian Dermatology.
This study found that 1064 nm QS Nd:YAG laser treatment effectively lightens hair and improves skin appearance in Indian subjects with minimal adverse effects, offering a safer alternative to chemical lightening products.
research Successful management of severe alopecia areata and vitiligo using topical delgocitinib and a 308-nm excimer laser
This study reported that therapeutic make-up significantly improves the long-term quality of life for patients with facial dermatoses, showing a sustained benefit one year after application, particularly in younger patients.
research 1327 Effect of ginsenoside Rd on dermal epidermal junction in fibroblast
This study found that treating human dermal fibroblast cells with ginsenoside Rd increased the expression of mRNA associated with the dermal-epidermal junction, suggesting potential as an anti-aging cosmetic ingredient.
research ISID1116 – Novel androgen receptor degrader for androgenetic alopecia (AGA) application
In this study, a newly designed protein degrader targeting androgen receptors showed promise in reversing hair regrowth inhibition in a mouse model of androgenetic alopecia, suggesting potential as a novel and safe treatment strategy.
research Rand Protease: The Role of Calcium-Binding Site on Stability with Mutagenesis and The Effectiveness on Leather Dehairing
In this study, researchers used in silico mutagenesis to identify key calcium-binding sites influencing the stability of Rand protease from Bacillus subtilis, potentially enhancing its application in industries like leather dehairing by improving stability and eliminating the need for additional metal ions during the process.
research Enzyme-linked immunosorbent assays for doping control of 5α-reductase inhibitors finasteride and dutasteride
This study reported the development of two highly sensitive ELISA assays to detect banned substances finasteride and dutasteride in human urine, offering better sensitivity than existing HPLC/MS/MS methods.
research High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase
This study reports that mutations in human L-PGDS affect the entrance and exit of ligands in its binding cavity, suggesting these residues play a role in ligand interaction processes.
research Treatment of Generalized Lichen Planus With Alefacept
This case report describes a 25-year-old woman with widespread lichen planus who did not respond to multiple systemic treatments, including antihistamines, hydroxychloroquine sulfate, and corticosteroids.
research Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device–Controlled Multicenter Trial
This study found that low-level light therapy significantly increased hair density and diameter in androgenetic alopecia patients compared to a sham device, suggesting it could be an effective treatment option.
research DecisionDx‐Melanoma and Sentinel Lymph Node Biopsy
This overview describes the Dermatologic Surgery journal's comprehensive focus on cosmetic and reconstructive skin procedures, but it reports no new research findings.
research Novel type 1 5a-reductase Inhibitors with Antiproliferative Potential on LNCaP cells
This study demonstrated that derivatives of dehydroepiandrosterone (2a-b, 3a-f, and 4a-f) significantly reduced viable LNCaP prostate cancer cells, suggesting potential therapeutic use for metastatic prostate cancer, while finasteride did not alter cell viability.
research The manifestation of discoid lupus erythematosus on the scalp
This case report describes a 47-year-old patient with scarred alopecia diagnosed as discoid lupus erythematosus, where treatment with multiple medications led to clinical improvement.
research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs
This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.