High-Resolution Structures of Mutants Affecting Access to the Ligand-Binding Cavity of Human Lipocalin-Type Prostaglandin D Synthase

    July 2014 in “ Acta Crystallographica Section D-biological Crystallography ”
    Massimiliano Perduca, Michele Bovi, M. Bertinelli … Hugo L. Monaco
    Studysummary This study reports that mutations in human L-PGDS affect the entrance and exit of ligands in its binding cavity, suggesting these residues play a role in ligand interaction processes.
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    Research cited in this study 2

    1. Structural and Dynamic Insights into Substrate Binding and Catalysis of Human Lipocalin Prostaglandin D Synthase Journal of Lipid Research · 2013
    2. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012