Comparative Effects of D-004, Imipramine, and Sertraline in the Forced Swimming Test in Mice

The study compared the effects of D-004, Imipramine, and Sertraline on mice using the forced swimming test to assess antidepressant activity. D-004, a lipid extract from the real palm fruit, was administered in doses of 100, 250, and 500 mg/kg over 14 days. It significantly reduced immobility time by 17-25% and increased swimming behavior by 1.58-1.74 times compared to the control group, indicating a moderate antidepressant effect. However, this was less effective than Sertraline and Imipramine, which reduced immobility by over 60%. Higher doses of D-004 also increased climbing behavior, similar to Imipramine but with lower efficacy. The findings suggested that D-004 could offer moderate antidepressant benefits for patients with benign prostatic hyperplasia, who often experience depressive symptoms.