This study identified distinct immune differences in patients with alopecia areata, particularly those with atopic backgrounds, and highlighted the OX40 axis as a potential therapeutic target for the condition.
July 2024 in “Journal of Investigative Dermatology” Allergies, especially both seasonal and food, increase the risk of developing alopecia areata.
In this retrospective study of alopecia areata patients across several European countries, researchers observed a notable reduction in SALT scores, but few patients reached or maintained a clinically significant SALT score of ≤20, indicating potentially limited effectiveness of current treatments for extensive hair loss.
February 2024 in “Lasers in Medical Science” This review discusses laser and energy-assisted drug delivery as a treatment for alopecia and concludes that although all studies show positive effects, some reports indicate no superiority over existing monotherapies.
September 2023 in “Cureus” This case report describes a four-month-old infant with atypical alopecia areata following a cultural head-shaving ritual, who showed improvement with topical triamcinolone treatment, though not full symptom resolution, highlighting the rarity and complexity of managing AA in infants.
July 2023 in “Al-Azhar Assiut Medical Journal” In this study, tinea capitis was identified as the most common cause of noncicatricial alopecia in children, followed by alopecia areata and marginal traction alopecia. Diagnosis using trichoscopy enhanced understanding by revealing specific hair and scalp disorder characteristics.
March 2023 in “International journal of trichology” This review discusses genetic conditions linked to complete scalp alopecia in children, identifying six genetic causes, but reports no new clinical results.
November 2022 in “Skin health and disease” This systematic review found a significant association between hair loss and mental health disorders such as major depressive disorder and anxiety, but it was unable to specify correlations for each type of hair loss.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study investigates whether lymphocytes from mice with secondary alopecia areata can effectively induce the disease in a C3H/HeH mouse model, similar to lymphocytes from mice with spontaneous disease.
May 2023 in “Journal of Applied Cosmetology” In this randomized controlled trial, researchers found that participants with androgenic alopecia taking an Annurca apple extract supplement showed significant increases in hair density and weight and reduced hair loss compared to a placebo, with good skin and gastrointestinal tolerability over 180 days.
April 2012 in “The Journal of Urology” This case-control study found that men with earlier onset androgenetic alopecia, particularly frontal balding, may have an increased risk of prostate cancer in a multiethnic veterans cohort.
December 2024 in “Mağallaẗ ʻulūm al-rāfidayn” In this study, zinc oxide nanoparticles were synthesized using a sustainable method from the Lepidium sativum L. plant, and incorporating these nanoparticles into Sunblock Lotion significantly increased its sun protection factor.
40 citations
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June 2021 in “Clinical, cosmetic and investigational dermatology” This review explores the efficacy and outcomes of using JAK inhibitors for treating alopecia areata, noting advancements in understanding the disease's pathomechanisms and suggesting that JAK inhibitors may offer targeted therapeutic benefits by blocking specific inflammatory pathways involved in this chronic condition.
25 citations
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December 2005 in “Molecular Genetics and Metabolism” This study reports that riboflavin may increase enzymatic activity in a GCDH-deficient patient with specific mutations, but doesn't fully normalize urinary organic acid levels.
8 citations
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October 2019 in “Immunological investigations” This study suggests that the rs2075876 variant in the AIRE gene may significantly increase susceptibility to alopecia areata in the examined male population.
36 citations
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January 2015 in “Dermatology” In this study, bimatoprost solution showed better results than corticosteroid in terms of rapidity, percentage of hair regrowth, and side effects for treating scalp alopecia areata.
15 citations
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March 2021 in “Journal of clinical medicine” This review discusses common skin eruptions caused by biologics in treating inflammatory bowel disease and proposes tailored therapeutic approaches for managing these adverse reactions.
April 2024 in “Dermatology and therapy” This study surveyed dermatologists in Greece and Italy and found significant variability and challenges in the diagnosis and treatment of alopecia areata, including limited use of severity scores and diverse treatment approaches, particularly for special site involvement and chronic cases.
January 2021 in “Journal of cosmetology & trichology” This study assessed Ageratum conyzoides gel's efficacy in reducing hair loss and improving quality of life in adults with pattern baldness, finding that it decreased temporal recession and improved hair-related distress scores, with a significant reduction in 5α-reductase expression and PGD2 release in vitro.
4 citations
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January 1994 in “Yakugaku zasshi” In this study, EPC-K, a compound with antioxidant and moisturizing effects, was found to decompose significantly under certain conditions, impacting its stability in quasi drug hair-growing products.
24 citations
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May 2010 in “Veterinary dermatology” This study found that both ciclosporin A and topical therapy were effective in reducing alopecia and scaling in dogs with idiopathic sebaceous adenitis, with evidence suggesting improved outcomes when both treatments are combined.
23 citations
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April 2021 in “Journal of Clinical Medicine” This review compiles existing data on frontal fibrosing alopecia and highlights the promise of 5-alpha reductase inhibitors as a treatment option, while noting the need for clarity on its cause and progression.
April 2024 in “Frontiers in medicine” This Delphi study found that moderate-to-severe alopecia areata in Poland, Czechia, Russia, and Türkiye significantly impacts quality of life and highlights an unmet need for more effective treatments.
147 citations
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January 2014 in “American Journal of Clinical Dermatology” This study found that low-level laser treatment with the HairMax Lasercomb significantly increased terminal hair density in both men and women with pattern hair loss, with no serious adverse events reported.
11 citations
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June 2012 in “Archives of Dermatological Research” This study demonstrated that high doses of L-cystine and vitamin B6 effectively prevent doxorubicin-induced hair loss in mice.
11 citations
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September 1996 in “Neuroscience letters” This study found that fetal calf serum can protect Merkel cells from death and alter their morphology in culture, while serum-free conditions led to high cell mortality.
185 citations
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February 2018 in “Journal of Investigative Dermatology” This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.
98 citations
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June 2008 in “Human mutation” This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.
75 citations
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June 2019 in “International Journal of Molecular Sciences” This review discusses the therapeutic potential of costunolide for various diseases, highlighting its bioactivity and mechanisms, but it reports no new experimental results.
70 citations
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June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This study reports that the TrichoScan method effectively measures hair growth parameters and detected significant improvements in hair counts and thickness in men with androgenetic alopecia after finasteride treatment.